September 20, afternoon
Opening Lectures

18.00-18.45 R. Modlin
Role of Toll-like receptors in host defense against microbial infection

18.45-19.30 D.Kasper
Polysaccharide mediated T-cell activation: a model of immunomodulation

19.30 WELCOME PARTY

September 21, morning
Bacterial initiators of cell activation (Chairmen R. Dziarski and K. Heeg)

8.20-9.00 R. Dziarski
Peptidoglycan recognition molecules in innate immunity

9.00-9.25 H. Heine
How LPS antagonists influence peptidoglycan signaling

9.25-10.05 T. Hartung
Endotoxic properties of lipoteichoic acid

10.05-10-30 J. Wang
Involvement of Toll-like receptors and CD14 in activation of human
leukocytes by highly purified lipoteichoic acid

10.30-10.55 H. Courtney
Proinflammatory responses to lipoteichoic acid

18.45-19.30 COFFEE BREAK

11.20-12.00 R. Schumann
Mechanisms of Streptococcus pneumoniae-induced innate immune responses

12.00-12.25 R. Malley
Pneumolysin and the innate immune response to pneumococci

12.25-12.50 M. Husmann
Stress response to pore forming toxins of gram positive bacteria

12.50-15.00 LUNCH BREAK

15.00-15.25 Jos Van Strip
Immune evasion by staphylococci

15.25-15.50 G. Teti
Innate immunity to group B streptococci

15.50-16.15 P. Henneke
Novel engagement of multiple toll-like receptors by group B streptococci

16.15-16.40 M. Fenton
Roles of Toll-like receptors in innate and acquired immune responses to
mycobacterial infection

Signal transduction (Chairman T. Espevik)

16.40-17.05 J. Cook
Signal transduction alterations in tolerance and cross-tolerance

17.05-17.30 C. McCall
IRAK is a pivotal link to inflammatory gene expression in innate defenses to
gram positive and gram negative microbial pathogens

17.30-17.55 B. Zingarelli
Effects of NF-kB inhibition in experimental sepsis

19.00 SOCIAL DINNER

September 22, a.m.
Toll-like receptors (Chairman D. Golenbock, S. Akira)

9.00-9.40 S. Akira
Toll-like receptors: A lesson from gene targeting

9.40-10.20 P. Tobias
Structure-function studies of TLR2 and its agonists

10.20-11.00 T. Espevik
Cell distribution and functions of TLRs

11.00-11.25 COFFE BREAK

11.25-12.05 D. Golenbock
Role of TLRs in LPS signaling

12.05-12.45 K. Heeg
TLRs trigger activation and inactivation of APC

12.45-13.10 M. Rehli
Toll-like receptor 2 gene expression in mononuclear phagocytes is regulated
by different promoters in man and mouse

13.10-15.00 LUNCH BREAK

15.00-15.25 D. Williams
Early upregulation of tissue Toll-like receptor 2 and 4 expression
correlates with mortality in polymicrobial sepsis

15.25-15.50 T. Flo
Involvement of TLR2 and TLR4 in activation of monocytes/macrophages with
mannuronic acid polymers

Innovative control strategies and pathogenesis (Chairmen J. Cook and P. Ferrieri)

15.50-16.30 P. Ferrieri
Immunologic strategies for the prevention of group B streptococcal
infections

16.30-16.55 Hilda Kari
Cellular response following stimulation with group B streptococcal
polysaccharides

16.55-17-20 J. Schreiber
Host response to bacterial polysaccharides and glycoconjugate vaccines

17.20-17.45 M. Jett
Use of gene discovery technology to establish biochemical pathways and
potential late-stage approaches for treatment of SEB-induced lethal shock

17.45-18.20 E. Jirillo
Role of lactoferrin in gram-negative infections and binding to LPS