TWENTY-SIXTH ANNUAL CONFERENCE ON SHOCK
Pointe Hilton Tapatio Cliffs Resort,
Phoenix, Arizona
June 7-10, 2003
FINAL PROGRAM
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TWENTY-SIXTH ANNUAL CONFERENCE ON SHOCK Pointe Hilton Tapatio Cliffs Resort, Phoenix, Arizona June 7-10, 2003 FINAL PROGRAM |
| 8:00 AM-2:00 PM Courtroom P | COUNCIL MEETING |
| 12:00 - 6:00 PM Ballroom Foyer | Registration |
| 1:30 -1:40 PM Salon ABCD | Welcome and Introduction Kathleen McDonough, PhD, Louisiana State University Health Sciences Center, New Orleans, LA |
| 1:45 - 2:45 PM | PLENARY SESSION I Insights Into Immune Modulation During Sepsis and Burn Injury, Papers 1-4 Moderator: Alfred Ayala, PhD, Brown University School of Medicine, Providence, RI |
| 1:45-2:00 PM | Association of RLT4 Genotype with Increased Risk of Severe Sepsis and Septic Shock Following Thermal Injury, Paper 1 Robert C. Barber, PhD, University of Texas Southwestern Medical Center at Dallas, Dallas, TX |
| 2:00-2:15 PM | A Role for CD1d-Restricted Natural Killer Cells in Burn-Induced Immune Dysfunction, Paper 2 Douglas E. Faunce, PhD, Loyola University Medical Center, Maywood, IL |
| 2:15-2:30 PM | Characterization of the Decreased Dendritic Cell Population in Murine Lymph Nodes During Polymicrobial Sepsis, Paper 3 Philip A. Efron, MD, University of Florida, Gainesville, FL |
| 2:30-2:45 PM | Factors Responsible for Suppressor of Cytokine Signaling (SOCS)-3 Upregulation in Polymicrobial Sepsis is Site-Specific, Paper 4 Patricia S. Grutkoski, PhD, Rhode Island Hospital/Brown University School of Medicine, Providence, RI |
| 2:45- 5:15 PM Salon ABCD | WORKSHOP I: Immunoresuscitation: The Immune Effects of Resuscitation Fluids Moderator: Carl Hauser, MD, University School of Medicine and Dentistry of New Jersey, Newark, NJ |
| 2:45-3:10 PM | The Inflammatory Effects of Asanguinous Fluids Peter Rhee, MD, University of Southern California, Los Angeles, CA Resuscitation fluids can cause inflammation. This talk will provide an overview of the differential effects of commonly used resuscitation fluids on inflammation. Hypo and isotonic crystalloids as well as artificial colloids can elicit immune activation and cellular injury whereas plasma, albumin and fresh blood do not. Hypertonic fluids may suppress inflammation by preserving cellular structure. Controlling resuscitation may prevent immune dysfunction better than trying to reverse established cellular injury. |
| 3:10-3:35 PM | The Immune Effects of Osmolarity Ori Rotstein, MD, University of Toronto, Toronto General Hospital, Toronto, Canada This presentation will review the cellular and molecular mechanisms that underlie the effects of hyperosmolar solutions on immune cell function and will discuss in-vivo models wherein hypertonic solutions have been shown to have immune modulatory effects. |
| 3:35-4:00 PM | The Immune Effects of Oxygen Carrying Solutions Ernest E. Moore, MD, Denver Health Medical Center Blood transfusions have immune effects that range from transplant and tumor tolerance to increased risks for infection after trauma. Blood products can contain inflammatory cytokines or lipids that prime PMNs and participate in ARDS. This presentation will discuss evolving concepts of the role of transfusion in the pathophysiology of organ failure. |
| 4:00-4:25 PM | The Immune Effects of Colloid Resuscitation Oliver Kempski, MD, Institute for Neurosurgical Pathophysiology, Johannes Gutenberg-University Mainz, Mainz, Germany This presentation will give an overview of the effects of colloids (albumin as well as artificial colloids) on leukocyte-endothelial interactions and on the immunology of shock and ischemia. In addition it will review published results and current research on 1) the effects of albumin on the mesenteric microcirculation after hemorrhagic shock in rats and 2) the effects of hypertonic/hyperoncotic treatment upon focal and global cerebral ischemia. |
| 4:25-4:50PM | The Clinical Uses of Hypertonic Fluids David Hoyt, MD, University of California San Diego, San Diego, CA The opportunity to modulate the immune responses to trauma and shock by means of their initial fluid resuscitation has great clinical potential. Laboratory observations to date are compelling, but they only represent phenomenology unless true clinical benefit can be demonstrated. This presentation will draw upon basic laboratory observations regarding the effects of fluid resuscitation on immune function, review the clinical studies of hypertonic fluids done to date, and define the clinical parameters and studies that need to be done to support their clinical use in the future. |
| 4:50-5:15 PM | Closing Discussion and Questions (Dr. Hauser and panel) |
| This program is supported by an unrestricted educational grant from Aventis Behring. | |
| 7:30 - 8:30 PM Salon ABCD | Presidential Keynote Address David Hoyt, MD University of California, San Diego |
| 8:30 - 9:30 PM Grotto Pool | WELCOME RECEPTION |
| 7:00 - 8:00 AM Pavillion | Continental Breakfast |
| 7:00 - 9:00 AM Courtroom MN | EDITORIAL BOARD BREAKFAST (Invitation only) |
| 7:00 - 10:00 AM Pavillion | POSTER SESSION I: Papers 5-71 Adhesion Molecules, Papers 5-6 Animal Models, Papers 7-11 Burn/Trauma, Papers 12-36 Cell Signaling, Papers 37-49 Cellular/Molecular, Papers 50-58 Clinical Applications, Papers 59-60 Cytokines, Papers 61-69 Eicosanoids/PAF, Papers 70-71 |
| 10:00 AM - 12:00 Salon ABCD | SYMPOSIUM I Genes and Shock Research Moderator: Gregory Bagby, PhD Louisiana State University Health Sciences Center, New Orleans, LA Speakers will discuss the role of genes in the response to injury and changes in gene expression in inflammation, sepsis and shock as assessed by analysis of gene expression by microarray techniques. The pros and cons of using transgenic and knockout animals to investigate mechanisms of injury and protection from injury will be presented. How variants of gene expression and polymorphisms impact the response to stressors and finally, the therapeutic potential of gene therapy will be presented. |
| 10:00-10:25 AM | What Can We Learn from Micorarray Analysis? J. Perren Cobb, MD, Washington University, St. Louis, MO |
| 10:25-10:50 AM | Use of Transgenic Animals in Research Klaus Ley, MD, University of Virginia, Charlotte, VA |
| 10:50-11:15 AM | Polymorphisms - How Do They Affect the Response to Inflammation and Injury Grant O'Keefe, MD, University of Washington, Seattle, WA |
| 11:15-11:40 AM | Gene Therapy in Shock Lyle Moldawer, PhD, University of Florida, Gainesville, FL |
| 11:40-12:00 PM | Panel Discussion and Questions |
| 10:30 - 11:00 AM Ballroom Foyer | Coffee Break |
| 12:00-1:30 PM Salon GHIJ | LUNCH |
| 12:00 - 1:30 PM Pavillion | Poster Discussion Session for New Investigators, moderated by Daniel Remick, MD, University of Michigan, Ann Arbor, MI |
| 1:45-3:00 PM Salon ABCD | New Investigator Competition (papers 72-76) Moderator: H. Hank Simms, MD, North Shore University Hospital, Manhasset, NY |
| 1:45-2:00 PM | Toll-Like Receptor 4 (TLR4) Coupled GI Protein Signaling Pathways Activate Extracellular Signal-Regulated Kinase (ERK1/2) Phosphorylation Independent of NFkB Activation. Paper 72 Hongkuan Fan, PhD, The Medical University of South Carolina, Charleston, SC |
| 2:00-2:15 PM | Oxidants in Hemorrhagic Shock Induce Lipid Raft Recruitment of Toll Like Receptor-4 (TLR-4). Paper 73 Kinga Powers, MD, University of Toronto, Toronto General Hospital, Toronto, Ontario, Canada |
| 2:15-2:30 PM | BCL-2 Inhibits Gut Epithelial Apoptosis but Does Not Improve Survival in Acute Lung Injury. Paper 74 Kareem D. Husain, MD, Washington University, St. Louis, MO. |
| 2:30-2:45 PM | Ageing and Caloric Restricted Diet Are Confounding Factors that Alter the Response to LPS by Peritoneal Macrophages from C57BL/6 Mice. Paper 75 Virginia L. Vega, PhD, Johns Hopkins University School of Medicine, Baltimore, MD |
| 2:45-3:00 PM | Modulation of Mitochondria-Dependent Neutrophil Apoptosis With Burn Injury. Paper 76 Zhihong Hu, MD, Loyola University Medical Center, Maywood, IL. |
| The New Investigator Competition is supported by an unrestricted educational gift from Pharmacia/Pfizer | |
| 3:00-3:30 PM Ballroom Foyer | Coffee Break |
| 3:30-5:30 PM Salon ABCD | Mini-Symposium I: Organ Injury and Mechanisms of Protection (Papers 77-86) Moderators: R. Wayne Barbee, PhD, Virginia Commonwealth University, Richmond, VA; Susan Stern, MD, University of Michigan, Ann Arbor, MI |
| 3:30-3:42 PM | Preliminary Studies Using Near Ultraviolet Excitation Fluorescence Spectroscopy to Monitor Tissue Dysoxia During Hemorrhage. Paper 77 R.Wayne Barbee, Virginia Commonwealth University, Richmond, VA. |
| 3:42-3:54 PM | Starling Curve Generation During Shock Resuscitation: Can It be Done? Paper 78 Alan.B. Marr, University of Texas-Houston Medical School, Memorial Hermann Hospital STICU, Houston, TX |
| 4:18-4:30 PM | Lipopolysaccharide-Binding Protein Modulates Hepatic Damage and lnflammatory Response After Hemorrhagic Shock and Resuscitation. Paper 81 Mark Lehnert, University of North Carolina, Chapel Hill, NC |
| 4:30-4:42 PM | IL-6 Plays A Major Role in Producing Hepatic Injury Following Trauma-Hemorrhage. Paper 82 Balazs Toth, University of Alabama at Birmingham, Birmingham, AL. |
| 4:42-4:54 PM | Glucagon Decreases Hepatic iNOS Synthesis In Vivo. Paper 83 Brian.G.Harbrecht, MD, University of Pittsburgh, Pittsburgh, PA |
| 4:54- 5:06 PM | Rapid Suppression of the LPS-Induced TNF Response by Physical Exercise and Ether Stress Through a B2-Adrenergic Mechanism. Paper 84 Gregory J. Bagby, Louisiana State University Health Sciences Center, New Orleans, LA |
| 5:06-5:18 PM | Attenuation of Local and Systemic Acute Inflammation by Acupuncture: Evidence for Cholinergic and Vagal Involvements. Paper 85 Shi Ping Zhang, School Chinese Medicine, Hong Kong Baptist University, Kowloon Tong, Hong Kong, PRC |
| 5:18-5:30 PM | Glutamine Attenuates the Metabolic Dysfunction of Sublethal Endotoxin Shock Via Manipulation of the Heat Stress Protein Pathway. Paper 86 Kristen D. Singleton, University of Colorado Health Sciences Center, Denver, CO |
| 3:30-5:30 PM Salon EF | Mini-Symposium II: Intracellular Signaling and Gene Expression (Papers 87-96) Moderators: Thomas Vary, PhD, Pennsylvania State College of Medicine, Hershey, PA and Linda Vona-Davis, PhD, Robert C. Byrd Health Science Center, Morgantown, WV |
| 3:30-3:42 PM | Sepsis-Induced Muscle Growth Hormone Resistance Occurs Independent of STAT Phosphorylation. Paper 87 Charles H. Lang, Pennsylvania State College of Medicine, Hershey, PA. |
| 3:42-3:54 PM | Nicotine Enhances Endothelial Cell (EC) Adhesion Molecule Expression Via p38 Mitogen Activated Protein Kinase (MAPK). Paper 88 Hirokazu Ueno, Chiba University Graduate School of Medicine, Chiba, Japan. |
| 3:54-4:06 PM | Fluorescence Resonance Energy Transfer (FRET) Analysis of Hypertonic Interference With Postendocytotic Inflammatory Signaling in Human Cells. Paper 89 Anirban Banerjee, University of Colorado, Denver, CO |
| 4:06-4:18 PM | Hyposia Disrupts iNOS Interaction with Alpha-Actinin 4 and Changes its Cellular Localization in Mouse Macrophages. Paper 90 Haim Bitterman, Carmel Medical Center, Faculty of Medicine, Technion, Haifa, Israel. |
| 4:18-4:30 PM | Differential Role of p38 And ERK 1/2 MAP Kinases in the Induction of Macrophage Hyperactivity Following Burn Trauma. Paper 91 Martin G. Schwacha, University of Alabama at Birmingham, Birmingham, AL. |
| 4:30-4:42 PM | Osmotic Stress Increases Phosphatidyl-Inositol 4,5 Bisphosphate (PIP2) Synthesis. Paper 92 Helen L.Yin, University of Texas, Southwestern Medical Center, Dallas, TX. |
| 4:42-4:54 PM | P-Glycoprotein is Upregulated by Hypoxic Stress in Enterocytes During Intestinal Inflammation. Paper 93 Faisal G. Qureshi, Children's Hospital of Pittsburgh, Pittsburgh, PA |
| 4:54-5:06 PM | Differential Gene Expression in Blood Leukocytes After LPS Administration to Human Volunteers: Effect of RNA Isolation Methods. Paper 94 Steve E. Calvano, (Inflammation and Host Response to Injury Large Scale Collaborative Research Program) UMDNJ-Robert Wood Johnson Medical School, New Brunswick, NJ |
| 5:06-5:18 PM | Gene Expression Profiles in Endotoxin-Tolerant Mouse Macrophages. Paper 95 Jianjun J. Gao, School of Medicine, University of Missouri, Kansas City, MO |
| 5:18-5:30 PM | Severity of Hemorrhagic Shock-Induced RBC Damage in Females Depends on the Stage of Estrus Cycle. Paper 96 Sergey Zaets, UMDNJ-New Jersey Medical School, Newark, NJ |
| 5:45-6:30 PM Grotto Pool | Reception for New Members/Travel Awardees/NIC (Invitation only) |
| 6:30-7:30 PM East Courtyard | Reception |
| 7:30-9:30 PM Salon GHIJ | Dinner/NIC & Travel Awards Ceremony |
| 6:00 - 7:00 AM Hotel Lobby | Annual Presidential Run |
| 7:00 - 8:00 AM Pavillion | Continental Breakfast |
| 7:00 - 10:00 AM Pavillion | POSTER SESSION II Papers 97-178 Endotoxin/Sepsis, Papers 97-128 Gene Regulation, Papers 129-132 Hemorrhagic Shock, Papers 133-178 |
| 10:00 - 12:00 PM Salon ABCD | SYMPOSIUM II: -Endotoxin Tolerance; from Bench to Bedside Moderator, James Cook, PhD, Medical University of South Carolina, Charleston, SC; co-moderator, Basilia Zingarelli, MD, PhD, University of Cincinnati, Cincinnati, OH Pretreatment with low concentrations of bacterial endotoxin induces resistance to subsequent lethal endotoxin challenge and re-programs macrophage/monocyte pro-inflammatory/anti-inflammatory mediator expression. This phenomenon, known as endotoxin tolerance, has been linked to multiple alterations in toll-like receptor signaling pathways. Experimentally, endotoxin tolerance can induce cross tolerance to other microbial products, and cross tolerance to ischemia/reperfusion injury. However there is also speculation that tolerance may be linked to immunoparalysis in SIRs patients and susceptibility to nosocomial infections. This symposium will address recent advances in molecular mechanisms of endotoxin tolerance, mechanisms of ischemia/reperfusion cross-tolerance, and the potential clinical relevance of this phenomenon in critically ill patients. |
| 10:00-10:20 AM | Perspectives on Endotoxin Tolerance James Cook, PhD Medical University of South Carolina, Charleston, SC |
| 10:20-10:40 AM | Cardiac Tolerance: A Crossword Puzzle Xianzhong Meng, MD, University of Colorado Health Sciences Center, Denver, CO |
| 10:40-11:00 AM | Is Tolerance Tolerable? Michael West, MD, PhD, Northwestern University, Chicago, IL |
| 11:00-11:20 AM | Endotoxin Tolerance: is There Clinical Relevance? Jean-Marc Cavaillon, Dr. Sc., Institut Pasteur, Paris, France |
| 11:20-11:30 AM | Key Issues in Endotoxin Tolerance Basilia Zingarelli, MD, PhD, University of Cincinnati, Cincinnati, OH |
| 11:30-12:00 PM | Panel Discussion and Questions |
| 10:30 - 11:00 AM Ballroom Foyer | Coffee Available |
| 12:00 - 1:00 PM Salon ABCD | BUSINESS MEETING |
| FREE AFTERNOON | |
| 1:00 - 8:00 PM | SPECIAL SESSION The Glue Grant will hold an afternoon meeting in conjunction with the annual Shock Society Meeting. The Glue Grant meeting will be held during the free afternoon on Monday, June 9, 2003. The first portion of the meeting will be open to the public. |
| 1:00 - 3:00 PM | Overview and brief progress reports (open meeting) |
| 3:00 - 6:00 PM | Breakout sessions for scientific cores (closed meeting) |
| 6:00 - 8:00 PM | Breakout session reports and dinner (closed meeting) |
| 7:00 - 8:00 AM Pavillion | Continental Breakfast |
| 7:00 - 10:00 AM Pavillion | POSTER SESSION III: Papers 179-261 Immunologic Dysfunction, Papers179-183 Immunomodulation, Papers 184-192 Inflammation, Papers 193-203 Ischemia/Reperfusion, Papers 204-212 Liver, Papers 213-214 Metabolism, Papers 215-219 Microcirculation, Papers 220-225 Monocytes/Macrophages, Papers 226-229 Multiple Organ Failure, Papers 230-232 Myocardial Function, Papers 233-235 Neural Aspects, Papers, 236-237 Neutrophils, Papers 238-242 Nitric Oxide, Papers 243-249 Oxygen Metabolites, Paper 250 Pharmacologic Agents, Papers 251-254 Pulmonary, Papers 255-259 Other, Papers 260-261 |
| 10:00 - 12:00 PM Salon ABCD | SYMPOSIUM III: Magic Bullets - What are the Most Reasonable Targets for Drug Therapy? Moderator, Daniel Remick, MD, University of Michigan, Ann Arbor, MI; co-moderator, Nicole Gibran, MD, University of Washington, Seattle, WA This symposium will focus on therapies for the treatment of sepsis or thermal injury. Most of the participants are aware of the numerous therapies that have failed in the past for the treatment of these conditions. A range of presentations will be made, which include identification of specific potential modulators of the inflammatory response as well as a broader view of the approach to identifying those factors which result in organ injury and death. Additionally, the roles of the neuro immune system and specific cellular dysfunction will be presented. It is hope that this symposium will present information, which is both cutting-edge as well as informative. |
| 10:00-10:25 AM | The Inflammatory Reflex Kevin Tracey, MD, North Shore University Hospital, Cornell University Medical College, Manhasset, NY |
| 10:25-10:50 AM | Systematic Approach to the Investigation of the Mediators of Sepsis Ronald Tompkins, MD, Massachusetts General Hospital, Harvard Medical School, Boston, MA |
| 10:50-11:15 AM | Inhibition of Lymphocyte Death in Sepsis: a New Therapeutic Strategy? Richard Hotchkiss, MD, Washington University, St. Louis, MO |
| 11:15-11:40 AM | Modulation of Lyn/Erk or Ca2+ Signaling Attenuates PMN Superoxide Generation Mohammed Sayeed, PhD, Loyola University, Chicago, IL |
| 11:40-12:00 PM | Panel Discussion and Questions |
| 10:30 - 11:00 AM Ballroom Foyer | Coffee Available |
| 12:00 - 1:30 PM Salon GHIJ | LUNCH |
| 1:30 - 3:30 PM Salon ABCD | WORKSHOP II: Good Molecules Gone Bad Moderator, Laurie Kilpatrick, PhD, Children's Hospital of Philadelphia, Philadelphia, PA The innate immune system is comprised of phagocytic cells such as neutrophils and monocytes which are the first line of defense against invading microorganisms. Inflammation triggers the activation of multiple proinflammatory pathways leading to the production of potent mediators such as TNF, C5a, oxygen radicals, NO and lipid metabolites. These mediators are important elements of host defense, but if not adequately regulated may also precipitate host tissue destruction associated with systemic inflammation. The inappropriate release of these mediators and subsequent damage to host tissue has been variously referred to as "an injury from within", "friendly fire injury" or "self-destructive bystander reaction". The focus of this workshop is on recent studies, which further define the role of these mediators in host tissue destruction and the regulatory mechanisms that control these potentially lethal mediators. |
| 1:30-1:55 PM | TNF Signaling in the Neutrophil: Friend or Foe? Laurie Kilpatrick, PhD, Children's Hospital of Philadelphia, Philadelphia, PA |
| 1:55-2:20 PM | A Protective Role for Lipoxins in the Airway Bruce Levy, MD, Harvard Medical School, Boston, MA |
| 2:20-2:45 PM | Good Complement Gone Bad Peter Ward, MD, University of Michigan, Ann Arbor, MI |
| 2:45-3:10 PM | Up to NO Good: The Janus-Faced Roles of Nitric Oxide in Physiological Regulation and Oxidative Stress Jack Lancaster, PhD, University of Alabama at Birmingham, Birmingham, AL |
| 3:10-3:30 PM | Panel Discussion and Questions |
| 3:30-5:45 PM Salon ABCD | Mini-Symposia III: Mechanisms of Endotoxin Tolerance and Tissue Injury Papers 262-271 Moderators: William Law, PhD, University of Illinois at Chicago, Chicago, Il and Avadhesh Sharma, PhD, North Dakota State University |
| 3:30-3:42 PM | Induction of Endotoxin Tolerance (ET) in the Absence of TLR4. Paper 262 Wyrta Heagy, Northwestern University, Chicago, IL. |
| 3:42-3:54 PM | Upregulation of Soluble TNF Receptor 1 (sTNFR1) Response to LPS During the Development of Endotoxin Tolerance. Paper 263 Daniel R.Meldrum, Indiana University Medical Center, Indianapolis, IN |
| 3:54-4:06 PM | Extracellular HSP-70: Potential Role in Endotoxin Tolerance. Paper 264 Rajesh Aneja, Cincinnati Children's Hospital Medical Center, Cincinnati, OH. |
| 4:06-4:18 PM | Lipoproteins Play a Regulatory Role in the Hepatic and Systemic Response to Endotoxin. Paper 265 F. Behzad Kasravi, University of California San Francisco, San Francisco, CA |
| 4:18-4:30 PM | Liver Sinusoidal Endothelial Cells Respond Directly to LPS, Possibly via Toll-Like Receptor 4 (TRL4). Paper 266 Nicole Kresge, University of North Carolina Charlotte, Charlotte, NC |
| 4:30-4:42 PM | Modulation of Endothelial Cell Activation by Bacterial Peptidoglycan-Associated Lipoprotein (PAL) Paper 267 Judith Hellman, Massachusetts General Hospital, Boston, MA |
| 4:42-4:54 PM | LPS Modulates Expression of Syndecan-1 and Bacterial Internalization by Enterocytes. Paper 268 Michelle J. Henry-Stanley, University of Minnesota, Minneapolis, MN. |
| 4:54-5:06 PM | The Differential Compartmentalization of CXC Chemokines Facilitates Neutrophil Recruitment in Response to Intra-Pulmonary Endotoxin. Paper 269 Lee J. Quinton, Louisiana State University Health Sciences Center, New Orleans, LA |
| 5:06-5:18 PM | Alpha-Chemokine Receptor Inhibitor Reduces HMGB-1 Induced Acute Lung Injury. Paper 270 Edmund J. Miller, North Shore-LIJ Research Institute. Manhasset, NJ |
| 5:18-5:30 PM | Reversing Established Sepsis with Antagonist of HMGB1. Paper 271 Huan Yang, North Shore LIJ Research Institute, Manhasset, NY. |
| 3:30-5:30 PM Salon EF | Mini-Symposia IV: Immune Modulation and Apoptosis in Sepsis and Burn Injury Papers 272-281 Moderators: Leona Rubin, PhD, University of Missouri, Columbia, MO and Stephen B. Jones, PhD, Loyola University of Chicago School of Medicine |
| 3:30-3:42 PM | Bone Marrow Monocyte Production is Markedly Enhanced in Mice Genetically Devoid of Endogenous Catecholamines. Paper 272 Stephen B. Jones, Loyola University Medical Center, Maywood, IL. |
| 3:42-3:54 PM | Differential Regulation of Neutrophil Cytokine Production During Sepsis by C5a. Paper 273 Niele.C. Riedemann, University of Michigan Medical School, Ann Arbor, MI. |
| 3:54-4:06 PM | Temperature Dependent Changes in PMN Respiratory Burst Depend on Altered Store Operated Calcium Entry. Paper 274 Carl J. Hauser, UMDNJ New Jersey Medical School, Newark NJ. |
| 4:06-4:18 PM | Advanced Age and Lymphocyte Function After Burn Injury. Paper 275 Elizabeth J. Kovacs, Loyola University Medical Center, Maywood, IL |
| 4:18-4:30 PM | b2 Microglobulin Knockout Mice are Resistant to Lethal Intraabdominal Sepsis. Paper 276 Edward R. Sherwood, University of Texas Medical Branch, Galveston, TX. |
| 4:30-4:42 PM | Adoptive Transfer of Apoptotic Splenocytes Worsens Survival While Adoptive Transfer of Necrotic Splenocytes Improves Survival in Sepsis. Paper 277 Isaiah R. Turnbull, Washington University School of Medicine, St. Louis, MO |
| 4:42-4:54 PM | Mesenteric Lymph from Male Rats Induces Endothelial Cell Apoptosis in a New In Vivo Model. Paper 278 Qi Lu, UMDNJ-New Jersey Medical School, Newark NJ. |
| 4:54-5:06 PM | Trauma Suppression of Bone Marrow Progenitor Cells is Prevented by Anti-Apoptotic Agents Both in Humans and Rats Paper 279. Ziad.C. Sifri, UMD, New Jersey Medical School, Newark, NJ |
| 5:06-5:18 PM | The Identification of Anti-Apoptotic Factors in NF-kB Mediated Apoptosis Inhibition in the Heart. Paper 280 Deborah L. Carlson, University of Texas, Southwestern Medical Center, Dallas, TX. |
| 5:18-5:30 PM | MAPK Regulation of Post-Ischemic Myocardial Apoptosis Paper 281 Theodore A. Christopher, Thomas Jefferson University, Philadelphia, PA |
| 6:30-7:30 PM West Courtyard | Reception |
| 7:30-9:30 PM Salon GHIJ | Dinner/Scientific Achievement & Service Awards Ceremony |
Conference Registration: Registration fees admit members, non-members and students@ to scientific sessions, social functions including the opening reception, coffee breaks and all meals except on the free afternoon (Monday lunch and dinner). Registration as spouse/guest permits a guest or spouse of the participant to attend meal and social functions at cost to the Society. This is a social registration - to be admitted to a scientific session you MUST be registered as a participant.
Registration FormStudent registrants must have a department head or research advisor certify student's eligibility. If registering at the meeting bring a student ID card or letter signed by your department head/advisor.
Meeting site: Pointe Hilton Tapatio Cliffs Resort, Phoenix, Arizona is approximately 20 minutes north of the Phoenix, Sky Harbor Airport. Accommodations: (each includes a two-room suite) whether in the main resort building or cliff side, features a spacious living room with executive work desk, conversation area, two dual-line telephones with dataports, and refrigerated minibar. Reservations can be made by fax (602) 870-2797 or by phone - Call reservation manager at 800-876-4683. NOTE: You will need to indicate that you are with the Shock Society to receive the special group rate and should be made by May 5, 2003 to guarantee rates ($135 for single or double).
Hotel RegistrationTravel arrangements: Phoenix Sky Harbor International Airport is served by 21 airlines, which provide nonstop service from Phoenix to 104 cities in the U.S. and around the world. America West Airlines and Southwest Airlines have major hub operations in Phoenix providing convenient connections to virtually any city in the U.S. Nonstop international service is provided by Aeromexico (to/from Mexico), British Airways (to/from London - Gatwick Airport), Lufthansa German Airlines (to/from Frankfurt, Germany), Air Canada (to/from Toronto and Calgary), and America West Airlines (to/from Canada and Mexico). The Pointe Hilton Tapatio Cliffs Resort is just 20 minutes from the airport.
Ground Transportation: Taxi, Van & Limo Transportation Phoenix Sky Harbor International Airport offers a variety of transportation options. Three taxi companies have contracted with Sky Harbor Airport to provide service to travelers for the following rates. There are no extra charges for more than one in the party or for baggage. You may choose any taxi you wish from the waiting line. The three companies are: AAA Cab (602) 437-4000, Allstate (602) 329-1017 and Discount (602) 266-1110. First Mile - $3.00, additional mile - $1.50 - airport surcharge $1.00.
Super Shuttle, operates 24 hours a day van service on a time scheduled basis. Vans depart to all areas of the Valley from 9 a.m. to 9 p.m. with lesser frequencies from 9 p.m. to 9 a.m. Fares are charged on a flat rate to each sector of geographic area. Call (602) 244-9000/voice or (602) 243-7786/TDD, for reservations. Super Shuttle Rate Information - Singe $10-$35.00 - Additional Person - $6.00
Unscheduled limousines offer airport-to-door service. Their rates include one or two in a party to the same address. The rate for three or more in one party to the same address is $7 for each additional passenger. Passengers are free to negotiate with the drivers for a lower rate, especially if the person waits for other passengers to load who will "share the fare."
Runners: Don't forget the 21st Annual Shock Society Presidential 5K Run
Race Registration
Details: For further information on the program, hotel, travel arrangements, 5-K run or conference registration contact Strategem, Inc. to obtain a complete program book (address below) or download it here (WordPerfect format, if you have problems downloading this then right-click the link and choose "Save Target As...").
We look forward to seeing you in Phoenix in June 2003.
Kathleen H. McDonough, Scientific Program Chair
(504) 568-6197
kmcdon@lsuhsc.edu
SHOCK 2003
C/o Strategem, Inc.
P.O. Box 1187
26064 Capital Drive - Suite A
Daphne, AL 36526
Fax: 334-625-4439
E-mail: curcur.msn.com
Aventis Behring
Pfizer
Office of Naval Research
Baxter-Healthcare
Sponsors
Cubist Pharmaceuticals
HyCult Biotechnology b.v.
Please join the Society in congratulating the following recipients of the 2003 Shock Society Travel Awards.
The session in which they will be presenting and their abstract numbers are listed below:
HongKuan Fan, PhD - The Medical University of South Carolina, Charleston, (Paper 72)
Kinga Powers, MD - University of Toronto, Toronto, Ontario, Canada (Paper 73)
Zhihong Hu, MD - Loyola University Medical Center, Chicago, Il (Paper 76)
Preya Ananthakrishnan, MD - UMDJN-New Jersey Medical School, Newark NJ (Paper 12)
Katherine Barness, MD - University of Colorado, Denver, CO (Paper 39)
Konstantin Umanskiy, MD - University of Cincinnati, Cincinnati, OH (Paper 47)
Dirk Henrich, Dr. phil.nat. - JW-Goethe University, Frankfurt, Germany, (Paper 52)
Octavia Peck - The Medical University of South Carolina, Charleston, SC (Paper 67)
Xiaoxuan Cui, MD,PhD - North Shore-Long Island Jewish Medical Center, Manhasset, NY (Paper 99)
Rongqian Wu, MD, PhD - North Shore Long Island Jewish Medical Center, Manhasset NY (Paper 126)
David Cohen, MD - New Jersey Medical School, Newark, NJ (Paper 138)
Claudio Lagoa, DVM - University of Pittsburgh, Pittsburgh, PA (Paper 150)
David Santone - Toronto General Hospital, Toronto, Ontario, Canada, (Paper 162)
Alia Shah - University of Texas Medical Branch, Galveston, Galveston, TX (Paper 163)
Albert Swafford - Louisiana State University Health Sciences Center, New Orleans, LA (Paper 167)
Hiroyuki Tanaka, PhD - University of Pittsburgh, Pittsburgh, PA (Paper 168)
Hiroyuki Tanaka, PhD - University of Pittsburgh, Pittsburgh, PA (Paper 168)
Niamh Choileain - Harvard Medical School, Boston, MA (Paper 179)
Jennifer Rietfors - University of California San Diego, San Diego, CA (Paper 191)
Forest Sheppard, MD - UCHSC and DHMC, Denver, CO (Paper 192)
Bashir Attuwaybi, MD - University of Texas, Houston, TX (Paper 194)
Joanne Lomas - University of Rhode Island/Rhode Island Hospital, Providence RI (Paper 197)
John Cha, MD - University of Colorado Health Sciences Center, Denver CO, (Paper 233)
Mark Lehnert, MD - University of North Carolina, Chapel Hill, NC (Paper 81)
HongKuan Fan, PhD - The Medical University of South Carolina, Charleston, (Paper 72)
Kinga Powers, MD - University of Toronto, Toronto, Ontario, Canada (Paper 73)
Kareem D. Husain, MD - Washington University School of Medicine, St. Louis, MO (Paper 74)
Virginia Vega - Johns Hopkins University School of Medicine, Baltimore, MD (Paper 75)
Zhihong Hu, MD - Loyola University Medical Center, Chicago, Il (Paper 76)
