| SATURDAY,
JUNE 3, 2000 |
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| 9:00 - 2:00 PM |
COUNCIL MEETING |
| White Pine |
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| 1:00 - 6:00 PM |
Registration |
| Ballroom Foyer |
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| 2:00 - 3:00 PM |
PENARY SESSION I,
Papers 1-5 |
| Ballroom 1 &
2 |
Moderators: Edwin
A. Deitch, MD , UMDNJ-New Jersey Medical School, Newark |
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and Gregory Bagby,
MD, Louisiana State University Medical Center, New Orleans |
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|
| 2:00
PM |
Post-Hemorrhagic
Shock Mesenteric Lymph (PHSML) Lipids Prime Neutrophil Superoxide
Production Via Phospholipase A2, Paper 1 |
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Ricardo J. Gonzalez,
MD |
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Denver Health Medical
Center, Denver, Colorado |
| 2:12
PM |
Non-Compartmentalization
of Granulocyte-Colony Stimulating Factor (G-CSF) Following
an Intrapulmonary Bacterial Challenge, Paper 2 |
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Gregory J. Bagby,
MD |
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Louisiana State
University Medical Center, New Orleans |
| 2:24
PM |
Glucose-6-P Dehydrogenase
(G6PD) Deficiency Predisposes to Sepsis, Worsens Anemia and
Results in a |
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Pronounced Activation
of Circulating Monocytes After Severe Trauma, Paper 3 |
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Zoltan Spolarics,
MD, PhD |
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UMDNJ- New Jersey
Medical School, Newark |
| 2:36
PM |
Burn Injury Induces
Expression of Two Novel Forms of the TIS11D Gene in |
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Mice, Paper 4 |
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Kristina G. Hobson,
MD |
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Shriners Hospitals
for Children, Sacramento, California |
| 2:48
PM |
The Role of INF-?
and IL-12 on Propioni-Bacterium (PA) Acnes-Primed LPS Hepatic
Injury, Paper 5 |
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Yoshiaki Shimizu,
MD |
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Washington University,
St. Louis, Missouri |
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|
| 3:00-5:00PM |
WORKSHOP I: Understanding
SIRS and MOF: Time to Change Perspective |
| Ballroom 1 &
2 |
Moderator: Gill
Cryer, MD, PhD, University of California, Los Angeles |
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Multiple Organ Failure
remains one of the most common causes of death after injury
or sepsis. |
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Despite incredible
advances in critical care technology over the last 30-40 years
the mortality rate |
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for this syndrome
remains very high. There have been tremendous gains in our
knowledge from basic |
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research, yet this
knowledge has not resulted in significant improvements in
outcome in the clinical setting. |
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Perhaps we need
to look at the problem differently. In this symposium we will
attempt to look at the problem |
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of Multiple Organ
Failure from different perspectives. Hopefully we will generate
new ideas, which may |
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eventually lead
to improved outcomes for patients suffering from this disease. |
| 3:00
PM |
Introduction |
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Gill Cryer, MD,
PhD |
| 3:10
PM |
Recent Advances
from Basic Research Tells Us It’s Time to Change |
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the Definitions
of SIRS and MOF |
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Edward Abraham,
MD, University of Colorado Health Sciences Center, Denver |
| 3:35
PM |
The Difference Between
MOF and SIRS is Really a Failure of Recovery |
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Timothy Buchman,
MD, PhD, Washington University School of Medicine, |
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St. Louis, Missouri |
| 4:00
PM |
The SIRS-MOF Continuum
is a Failed Dynamic Balancing Act Across Time |
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John Mannick, MD,
Harvard Medical School, Boston, Massachusetts |
| 4:25
PM |
The Solution to
SIRS and MOF: A Challenge for the New Millennium |
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Eugen Faist, MD,
Ludwig-Maximilians-Universität, München Germany |
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|
| 7:30-8:30PM |
KEYNOTE ADDRESS:
Oh, the Places You’ll Go: Will You Succeed? You Will |
| Ballroom 1 &
2 |
Indeed! 99 and 3/4
Percent Guaranteed |
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Jureta W. Horton,
PhD, President-Elect, University of Texas Southwestern |
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Medical School,
Dallas |
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|
| 8:30 - 9:30 PM |
OPENING RECEPTION
|
| Conference Center
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| Terrace |
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| SUNDAY, JUNE
4, 2000 |
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| 7:00 - 8:00 AM |
EDITORIAL BOARD
BREAKFAST |
| Maybird |
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| 7:00 - 8:00 AM |
Continental Breakfast |
| Ballroom 3, Magpie
& |
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| Golden Cliff |
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| 7:00 - 9:00 AM |
POSTER SESSION I,
Papers 6-76 |
| Ballroom 3, Magpie
& |
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| Golden Cliff |
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Adhesion Molecules,
Paper 6 |
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Animal Models, Papers
7-10 |
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Burn/Trauma, Papers
11-18 |
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Cellular/Molecular,
Papers 19-21 |
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Cytokines, Papers
22-30 |
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Eicosanoids/PAF,
Paper 31 |
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Endotoxin/Sepsis,
Papers 32-48 |
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Gene Regulation,
Paper 49 |
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Immunologic Dysfunction,
Paper 50 |
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Immunomodulation,
Papers 51-55 |
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Inflammation, Papers
56-58 |
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Metabolism, Papers
59-60 |
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Microcirculation,
Papers 61-66 |
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Monocytes/Macrophages,
Paper 67 |
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Multiple Organ Failure,
Papers 68-69 |
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Myocardial Function,
Papers 70-72 |
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Neonatology, Paper
73 |
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Pulmonary, Paper
74 |
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Renal, Papers 75-76 |
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|
| 9:00 - 10:00 AM |
PLENARY SESSION
II, Papers 77-81 |
| Ballroom 1 &
2 |
Moderator: William
Cheadle, PhD, Veterans Administration Medical Center, |
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Louisville, Kentucky
and Mark Carlson, PhD, Veterans Administration |
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Medical Center,
Omaha, Nebraska |
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|
| 9:00
AM |
LPS-Induced, Imbalanced
Expression of Hepatic Vascular Stress Genes |
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in Cirrhosis: Mechanism
of Increased Susceptibility to Endotoxemia, |
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Paper 77 |
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Rajiv Baveja |
| |
University of North
Carolina, Charlotte |
| 9:12
AM |
Role of Nitric Oxide
in Hemorrhagic Shock-Induced Hepatic Heme |
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Oxygenase-1 Expression
in the Rat, Paper 78 |
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Alexander Hoetzel,
MD |
| |
University of Freiburg,
Germany |
| 9:24
AM |
Interleukin (IL)-6
Knockout Attenuates Early Sepsis-Associated Hepatic Gene |
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Downregulation but
Increases Hepatic Necrosis and Death, Paper 79 |
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Patrick K. Kim,
MD |
| |
University of Pennsylvania,
Philadelphia |
| 9:36
AM |
A Dominant Role
of P55 TNF-a Receptor in Endotoxemic Myocardial |
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Dysfunction, Paper
80 |
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Xianzhong Meng |
| |
University of Colorado
Health Sciences Center, Denver |
| 9:48
AM |
Evidence for a Role
of NF-?B in Acute Hypovolemic Hemorrhagic Shock |
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in Rats, Paper 81 |
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Francesco Squadrito,
MD |
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University of Messina,
Italy |
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|
| 10:00 AM - 12:00
PM |
SYMPOSIUM I: Signal
Transduction and Genetic Regulation of Inflammation |
| Ballroom 1 &
2 |
Moderator: Timothy
Buchman, MD, PhD, Washington University School |
| |
of Medicine, St.
Louis, Missouri |
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In this session,
the speakers will explore the regulatory responses to inflammation
with a focus on balance |
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among intracellular
pathways. Dr. DeMaio will speak on the diversity of responses
and address |
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genotype-phenotype
relationships. He will describe approaches to the identification
of genes which modulate |
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the inflammatory
response. Dr. Giroir will focus on TNF-a and the consequences
of having too much, or too |
| |
little of this signalling
molecule at the surface of a cell. Dr. Callery will describe
how binding of specific ligands |
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changes the state
of second messenger intermediates a systematic and reciprocally
regulated mechanism. |
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Dr. Moldawer will
discuss disruption of regulatory responses using gene therapy
as an investigative tool. |
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Dr. Cobb will compare
and contrast the reductionist analysis of single gene responses
with the connectionist |
| |
analysis afforded
by gene arrays ("chips") in the study of inflammatory
responses. This session will emphasize |
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networks over pathways
and focus on the idea that the state of biological networks
is regulated by competing |
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stimuli and not
by isolated signals. |
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|
| 10:00
AM |
Genetic Diversity
in the Response to Canonical Inflammatory Stimuli |
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Antonio DeMaio,
PhD, Johns Hopkins University School of Medicine, |
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Baltimore, Maryland |
| 10:24
AM |
TNF-a: Inflammation
in Moderation |
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Brett Giroir, MD,
University of Texas Southwestern Medical School, Dallas |
| 10:48
AM |
Balanced Responses
of the Second Messenger Pathways to Inflammation |
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Mark P. Callery,
MD, University of Massachusetts Medical School, Worcester |
| 11:12
AM |
Gene Therapy as
a Strategy for Modulating the Response to Inflammation |
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Lyle L. Moldawer,
PhD, University of Florida College of Medicine, Gainesville |
| 11:36
AM |
Top-Down (Arrays)
Versus Bottom-Up (Specific Gene) Approaches to the |
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study of Responses
to Inflammation |
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J. Perren Cobb,
MD, PhD, Washington University, St. Louis, Missouri |
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|
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|
| 10:45 - 11:00 AM |
Coffee Available |
| Ballroom Foyer |
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|
| 12:00 - 1:30 PM |
Lunch |
| Cottonwood 1-4 |
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|
| 1:45 - 3:15 PM |
YOUNG INVESTIGATOR
AWARD SESSION, Papers 82-85 |
| Ballroom 1 &
2 |
Presiding: Mohammed
M. Sayeed, PhD, Loyola University, Maywood, Illinois |
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|
| 1:45
PM |
Cytokine-Induced
Enterocyte-Derived Nitric Oxide Induces Intestinal |
| |
Monolayer Injury
in an Autocrine Fashion, Paper 82 |
| |
Raquel M. Forsythe,
MD |
| |
UMDNJ-New Jersey
Medical School, Newark |
| 2:00
PM |
Progesterone Improves
Cardiovascular Function Following Trauma- |
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Hemorrhage and Resuscitation,
Paper 83 |
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Joachim Friedrich
Kuebler, MD |
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Rhode Island Hospital,
Providence |
| 2:15
PM |
Do Peripheral Blood
Mononuclear Cells Mimic the Sexually Dimorphic |
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Immune Response
of Tissue Immune Cells Following Trauma-Hemorrhage?, |
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Paper 84 |
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Christian P. Schneider,
MD |
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Rhode Island Hospital,
Providence |
| 2:30
PM |
Glutamine Induces
Heat Shock Protein and Prevents Mortality from |
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Endotoxemia in the
Rat, Paper 85 |
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Paul E. Wischmeyer,
MD |
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University of Chicago,
Illinois |
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| 3:00 - 3:30 pm |
Coffee Break |
| Ballroom Foyer |
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| 3:30 - 5:30 PM |
MINISYMPOSIUM I,
Papers 86-95 |
| Ballroom 1 &
2 |
Moderator: Alfred
Ayala, PhD, Rhode Island Hospital, Providence and |
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Inge Bauer, PhD,
University of Saarland, Homburg, Germany |
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|
| 3:30
PM |
Intraluminal Nutrients
Enhance Gut Ischemia/Reperfusion Injury, |
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Paper 86 |
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Rosemary Kozar,
MD, PhD |
| |
University of Texas
Medical School, Houston |
| 3:42
PM |
Effects of the Secretion
of Metabolic Regulating Hormones (Leptin) and |
| |
Posttraumatic Complications
in Blunt Polytrauma Patients, Paper 87 |
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Martijn van Griensven,
PhD |
| |
Hannover Medical
School, Germany |
| 3:54
PM |
Delayed Blockage
of FasL Restores Lymphoid Immune Function, Suppresses Apoptosis
and Improves Survival in Sepsis, Paper 88 |
| |
Chun-Shiang Chung,
PhD |
| |
Rhode Island Hospital,
Providence |
| 4:06
PM |
Role of Kupffer
Cells and Neutrophils for the Regulation of Heme Oxygenase- |
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1 Gene Expression
in the Liver Under Stress Conditions, Paper 89 |
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Markus Paxian, MD |
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University of Saarland,
Homburg, Germany |
| 4:18
PM |
Expression Pattern
and Regulation of Heme Oxygenase-1/Heat Shock Protein |
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32 in Human Liver
Cells, Paper 90 |
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Inge Bauer, PhD |
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University of Saarland,
Homburg, Germany |
| 4:30
PM |
Endotoxin Mediated
Blockade of Pregnane X Receptor Translocation: Effects |
| |
on Hepatic Cytochrome
P-450, Paper 91 |
| |
Clinton Chichester |
| |
University of Rhode
Island College of Pharmacy, Kingston |
| 4:42
PM |
Flagellin, A Novel
Mediator of Gram Negative Bacteria-Induced Shock |
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Paper 92 |
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Andrew L. Salzman,
MD |
| |
Inotek Corporation,
Beverly, Massachusetts |
| 4:54
PM |
CD16 Blockade in
Polymicrobial Sepsis Increases Hepatic but Not Pulmonary |
| |
Neutrophil Sequestration,
Paper 93 |
| |
Stephen A. Rowe,
MD |
| |
Veterans Administration
Medical Center, Louisville, Kentucky |
| 5:06
PM |
Adenosine-Mediated
Alterations in Testicular Cytokine and Testosterone |
| |
Production, Paper
94 |
| |
Andrew M. Clark,
BA |
| |
University of Illinois
at Chicago, Illinois |
| 5:18
PM |
Posttraumatic Disturbances
of Humoral Bone Factors in Trauma Patients, |
| |
Paper 95 |
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Otmar A. Trentz,
MD |
| |
University Hospital,
Zurich, Switzerland |
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|
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|
| 3:30 - 5:30 PM |
MINISYMPOSIUM II,
Papers 96-105 |
| Superior A &
B |
Moderators: Jureta
W. Horton, PhD, University of Texas Southwestern Medical |
| |
Center, Dallas and
J. Perren Cobb, MD, Washington University, St. Louis, |
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Missouri |
| |
|
| 3:30
PM |
Effects of Lactated
Ringers on Cardiomyocyte TNF-a Synthesis, |
| |
Paper 96 |
| |
Jureta W. Horton,
PhD |
| |
University of Texas
Southwestern Medical Center, Dallas |
| 3:42
PM |
Microvascular Effects
of Oral IL-6, Paper 97 |
| |
F.M. Rollwagen,
PhD |
| |
Uniformed Services
of the Health Sciences, Bethesda, Maryland |
| 3:54
PM |
Removal of Fatty
Acids Improves Coupling of Ex-Vivo Myocardial Glycolytic |
| |
Flux to Glucose
Oxidation After Hemorrhage, Paper 98 |
| |
Lisa T. Thornton |
| |
Carolinas Medical
Center, Charlotte, North Carolina |
| 4:06
PM |
Sepsis Gene Expression
Profiling: Murine Splenic Compared to Hepatic |
| |
Responses Determined
Using cDNA Microarrays, Paper 99 |
| |
J. Perren Cobb,
MD |
| |
Washington University,
St. Louis, Missouri |
| 4:18
PM |
Genetic Disruption
of Poly (ADP-Ribose) Synthethase Reduces Gut\ |
| |
Dysfunction and
Distant Organ Damage in Mesenteric Ischemia-Reperfusion |
| |
Injury, Paper 100 |
| |
Lucas Liaudet |
| |
Inotek Corporation,
Beverly, Massachusetts |
| 4:30
PM |
Post Hemorrhagic
Shock Mesenteric Lymph Upregulates E-Selectin |
| |
Expression in Human
Umbilical Vein Endothelial Cells (HUVEC), |
| |
Paper 101 |
| |
Justin T. Sambol,
MD |
| |
UMDNJ-New Jersey
Medical School, Newark |
| 4:42
PM |
A Time Course Study
of the Protective Effect of Mesenteric Lymph Duct |
| |
Ligation on Hemorrhagic
Shock-Induced Pulmonary Injury and the Toxic |
| |
Effects of Shock
Lymph on HUVEC Cell Monolayer Permeability, Paper 102 |
| |
Edwin A. Deitch,
MD |
| |
UMDNJ- New Jersey
Medical School, Newark |
| 4:54
PM |
LBP Promotes Bacterial
Killing of Silver Sulfadiazine Resistant P. Aeruginosa |
| |
in Infected Burn
Wounds, Paper 103 |
| |
Richard D. Klein |
| |
University of Michigan,
Ann Arbor |
| 5:06
PM |
Distribution of
Monohydroxy Fatty Acids (MHA) in Murine Skin Following |
| |
Thermal Injury,
Paper 104 |
| |
Kenneth Langen |
| |
Loyola University
Medical Center, Maywood, Illinois |
| 5:18
PM |
Which Receptor Mediates
Prostaglandin E2 (PGE2)/Thromboxane A2 |
| |
Synergy?, Paper
105 |
| |
F. Mahzari, BS |
| |
University of Texas
Southwestern Medical School, Dallas |
| |
|
| 6:30 - 7:30 PM |
RECEPTION |
| Ballroom Lobby |
|
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|
| 7:30 - 9:30 PM |
DINNER/SPEAKER |
| Ballroom 1 &
2 |
|
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|
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|
| MONDAY, JUNE 5, 2000 |
|
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|
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|
| 6:30
AM |
Eighteenth Annual
Presidential Run |
| Meet in Lobby |
|
| 8:00 - 9:00 AM |
Continental Breakfast |
| Ballroom 3, Magpie
& |
|
| Golden Cliff |
|
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|
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|
| 9:00 - 10:00 AM |
PLENARY SESSION
III, Papers 106-110 |
| Ballroom 1 &
2 |
Moderators: Ronald
V. Maier, MD, Harborview Medical Center, Seattle, |
| |
Washington and Lyle
Moldawer, PhD, University of Florida College of Medicine, |
| |
Gainesville |
| |
|
| 9:00
AM |
Mitogen-Activated
Protein Kinases (MAPK) in the ICU: Potential Prognostic |
| |
Factors, Paper 106 |
| |
Matthew R. Rosengart,
MD |
| |
Harborview Medical
Center, Seattle, Washington |
| 9:12
AM |
Protegrin-1 Enhances
Bacterial Killing in Thermally Injured Murine Epidermis, |
| |
Paper 107 |
| |
Lars Steinstresser |
| |
University of Michigan,
Ann Arbor |
| 9:24
AM |
Burn-Induced T Cell
Suppression is Prevented After Neutrophil Depletion in |
| |
Burn-Injured Rats,
Paper 108 |
| |
Thyyar M. Ravindranath |
| |
Loyola University
Medical Center, Maywood, Illinois |
| 9:36
AM |
STAT 5/6 Protein
and Cytokine Expression, Paper 109 |
| |
Vicky Chappell,
MD |
| |
University of Texas
Medical Branch, Galveston |
| 9:48
AM |
The Inflammatory
Response in Severely Injured Patients Following Small |
| |
Volume Resuscitation,
Paper 110 |
| |
U.C. Liener, MD |
| |
University of Ulm,
Germany |
| |
|
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|
| 10:00AM-12:00PM |
SYMPOSIUM II: Neuro
Endocrine Interaction: Regulation of Responses |
| Ballroom 1 &
2 |
to Shock and Trauma |
| |
Moderator: Naji
N. Abumrad, MD, North Shore University Hospital, Manhasset, |
| |
New York |
| |
|
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|
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Understanding the
control mechanisms involved in modulation of the hemodynamic,
pro-inflammatory, metabolic and immune |
| |
responses which
occur during the ebb and flow phases following injury is crucial
in order to establish optimal intervention paradigms |
| |
for the critically
ill individual. Studies using various models of physical stress,
including hemorrhagic and endotoxic shock, trauma |
| |
and hypoclycemia,
have provided significant evidence of a critical role for
neuro-endocrine control of these responses. The pathways |
| |
involved in modulation
of the magnitude and time course of these post-traumatic stress
responses are not limited to |
| |
hypothalamo-pituitary-axis
activation, but include central and peripheral release of
opioids, excitatory amino acids, serotonin and nitric |
| |
oxide. These neuro-endocrine
mediators play redundant, adjuvant or opposing roles affecting
the wide array of immune, metabolic |
| |
and hemodynamic
responses, which comprise the post-injury phase. The aim of
this symposium is to highlight some of the recent |
| |
advances in the
understanding of neuro-endocrine control of select responses
to shock, trauma and sepsis. |
| |
|
| 10:00
AM |
Introduction |
| |
Naji N. Abumrad,
MD |
| 10:12
AM |
Modulation of Trauma/Shock-Induced
Responses; Interaction of Monoamine |
| |
and Opiate Pathways |
| |
Patricia E. Molina,
MD, PhD, Louisiana State University Health Science |
| |
Center, New Orleans |
| 10:39
AM |
The Stress/Septic
Response: The Role of IGF and Growth Hormone |
| |
Charles Lang, PhD,
Penn State College of Medicine, Hershey |
| 11:06
AM |
The Role of Central
Parasympathica Systems in the Stress/Septic Response |
| |
Kevin Tracy, MD,
Cornell University Medical College, Manhasset, New York |
| 11:33
AM |
The Role of Adrenomedullin
in the Septic Response |
| |
Ping Wang, MD, Brown
University and Rhode Island Hospital, Providence |
| |
|
| 10:30 - 11:00 AM |
Coffee Available |
| Ballroom Foyer |
|
| |
|
| 12:00-1:00 PM |
BUSINESS MEETING |
| Ballroom 1 &
2 |
|
| |
|
| FREE AFTERNOON |
|
| |
|
| |
|
| TUESDAY, JUNE
6, 2000 |
|
| |
|
| 7:00 - 8:00 AM |
Continental Breakfast |
| Ballroom 3, Magpie
& |
|
| Golden Cliff |
|
| |
|
| 8:00 - 9:00 AM |
POSTER SESSION II,
Papers 111- 179 |
| Ballroom 3, Magpie
& |
|
| Golden Cliff |
|
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|
| |
Cell Signaling,
Papers 111-121 |
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Hemorrhagic Shock,
Papers 122-152 |
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Neutrophils, Papers
153-161 |
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Nitric Oxide, Papers
162-167 |
| |
Oxygen Metabolites,
Papers 168-169 |
| |
Pharmacology, Papers
170-174 |
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Ischemia/Reperfusion,
Papers, 175-178 |
| |
Liver, Paper 179 |
| |
|
| 9:00 - 10:00 AM |
PLENARY SESSION
IV, Papers 180-184 |
| Ballroom 1 &
2 |
Moderators: Carol
Miller-Graziano, PhD, University of Massachusetts |
| |
Medical Center,
Worcester and James A. Thomas, MD, University of Texas |
| |
Southwestern Medical
Center, Dallas |
| |
|
| 9:00
AM |
Inducible Nitric
Oxide Synthase Is Required for Enterocyte Apoptosis |
| |
After Hemorrhagic
Shock, Paper 180 |
| |
Evan P. Nadler,
MD |
| |
Children’s Hospital
of Pittsburgh, Pennsylvania |
| 9:12
AM |
IRAK Mediates Postburn
Myocardial Contractile Dysfunction, |
| |
Paper 181 |
| |
James A. Thomas,
MD |
| |
University of Texas
Southwestern Medical Center, Dallas |
| |
Tuesday Continued |
| |
|
| 9:24
AM |
Depressed Trauma
Patient MØ IL-18 Levels Lead to Decreased T Cell IL-13 |
| |
Levels, Paper 182 |
| |
Carol Miller-Graziano,
PhD |
| |
University of Massachusetts
Medical School, Worcester |
| 9:36
AM |
Inhibition of LPS-Induced
ERK ½ Activation and I?Ba Degradation by |
| |
15-Deoxy-?12,14-PGJ2
, Paper 193 |
| |
Kelly Guyton, BS |
| |
Medical University
of South Carolina, Charleston |
| 9:48
AM |
Cerebral Perfusion
Pressure (CPP) Directed Therapy After Traumatic Brain |
| |
Injury (TBI), Paper
194 |
| |
Ajai K. Malhotra,
MD |
| |
University of Tennessee
Health Science Center, Memphis |
| |
|
| 10:00 AM - 12:00
PM |
SYMPOSIUM III: Understanding
of Myocardial Dysfunction in Hyper |
| Ballroom 1 &
2 |
Inflammatory States |
| |
Moderator: Kathleen
McDonough, PhD, Louisiana State University, New Orleans |
| |
|
| |
The myocardium is
responsible for pumping a cardiac output to match the tissue’s
requirements for blood flow. Alterations in |
| |
myocardial function
are normally elicited by changes in preload, afterload, contractility
and heart rate. However, during inflammatory |
| |
states, sepsis and
compromised myocardial blood flow, changes in myocardial contractile
function can occur through other |
| |
influences such
as acidemia, cytokines and chemokines, oxygen radicals and
a number of other mediators that my be produced in |
| |
an inflammatory
state. The aim of this symposium is to present an update of
t he intracellular mechanisms by which myocardial |
| |
contractile function
is depressed and the role of cytokines in this myocardial
depression. In response to injury, the myocardium can |
| |
upregulate protective
functions that serve to blunt the negative consequences of
a second insult to the heart. Mechanisms involved in |
| |
inducing cardioprotection,
including the potential role of cytokines, will be discussed.
Methods to assess and treat myocardial |
| |
dysfunction in the
clinical setting will be presented. Finally, the issues of
potential mechanisms of injury versus mechanisms that |
| |
have actually been
shown to contribute to dysfunction in a pathophysiological
state will be discussed. |
| |
|
| 10:00
AM |
Alterations in Myocardial
Cell Signaling and Calcium Homeostasis as a |
| |
Mechanism of Myocardial
Depression |
| |
Leona Rubin, PhD,
University of Missouri, Columbia |
| 10:24
AM |
Cytokine Induced
Myocardial Depression and Protection |
| |
Alden Harken, MD,
University of Colorado, Denver |
| 10:48
AM |
Myocardial Preconditioning
by Ischemia and Sepsis |
| |
James Downey, MD,
University of South Alabama, Mobile |
| 11:12
AM |
Similarities and
Difference Between Cell and Whole Heart Models of |
| |
Myocardial Responses
to Sepsis |
| |
Kathleen McDonough,
PhD, Louisiana State University, New Orleans |
| 11:36
AM |
Advances in Quantifying
and Treating Myocardial Dysfunction During Critical |
| |
Illness: From Bench
to Bedside |
| |
Michael Chang, MD,
Wake Forest University School of Medicine, Winston-Salem,
North Carolina |
| |
|
| |
|
| 10:30 - 11:00 AM |
Coffee Available |
| Ballroom Foyer |
|
| |
|
| |
|
| 12:00 - 1:30 PM |
Lunch |
| Cottonwood 1-4 |
|
| 1:30 - 3:30 PM |
WORKSHOP II: Recent
Adjuncts to Resuscitation Strategies to |
| Ballroom 1 &
2 |
Prevent the SIRS
to MOF Progression: Bench to Bedside |
| |
Moderator: Kenneth
Proctor, PhD, University of Tennessee, Memphis |
| |
|
| |
After severe trauma
and blood loss, aggressive fluid resuscitation may be the
only hope for saving the patient. At the same time, |
| |
reperfusion promotes
reactive oxygen metabolite generation and activates PMNs in
splanchnic and other tissues that are already |
| |
expressing multiple
cytokines and endothelial cell surface adhesion molecules.
The resultant hyper-inflammatory state can produce |
| |
secondary injury
locally in otherwise undamaged cells, can spill over into
remote organs (e.g. lung), or can propagate into a |
| |
malignant unregulated
systemic response leading to SIRS or MOF. One speaker will
describe clinically-relevant models of battlefield |
| |
injuries designed
to mimic these conditions. The second speaker will describe
the benefits of a novel blood substitute in urban |
| |
trauma patients,
compared to other resuscitation fluids and compared to a potential
transfusion-induced cytotoxicity caused by stored, |
| |
packed RBCs. The
third speaker will consider novel strategies in the critically
ill trauma patient that combine adequate cellular |
| |
resuscitation and
avoidance of splanchnic vasopressors. Such strategies prevent
or ameliorate the ravages of unfettered oxidative |
| |
stress using agents
that attenuate or block unregulated cytotoxin formation and
"unprime" PMNs and are initiated in the trauma |
| |
resuscitation area,
ER, or surgical OR. The final speaker will provide an updated
review on a number of the clinical trials of new |
| |
therapeutic agents
for the adjuvant treatment of shock, sepsis, and/or SIRS which
have just closed to enrollment, are in progress, or |
| |
are in the final
planning stages. |
| |
|
| 1:30
PM |
Resuscitation Strategies
to Minimize End Organ Damage in Large Animal |
| |
Models of Shock
Related MOF |
| |
Kenneth Proctor,
PhD |
| 2:00
PM |
Blood Resuscitation:
Part of the Solution or Part of the Problem? |
| |
Ernest E. Moore,
MD, University of Colorado Health Sciences Center, Denver |
| 2:30
PM |
Resuscitation Strategies
to Minimize SIRS & Multiple Organ Failure |
| |
by Preventing Ischemia-Reperfusion
in Trauma Patients |
| |
Orlando Kirton,
MD, Hartford Hospital, Hartford, Connecticut |
| 3:00
PM |
Update on Current
Clinical Trials of Adjuncts to Resuscitation to Prevent |
| |
and/or Treat SIRS
and MOF |
| |
Mitchell Fink, MD,
University of Pennsylvania Medical Center, Pittsburgh |
| |
|
| 3:00 - 3:30 pm |
Coffee Available |
| Ballroom Foyer |
|
| |
|
| 3:30 - 6:00 PM |
MINISYMPOSIUM III,
Papers 185-196 |
| Ballroom 1 &
2 |
Moderators: H. Hank
Simms, MD, Rhode Island Hospital, Providence and |
| |
Richard Hotchkiss,
MD, Washington University, St. Louis, Missouri |
| |
|
| 3:30
PM |
Effects of Fluid
Resuscitation in Cerebral Intracellular Calcium in Traumatic |
| |
Brain Injury Associated
with Hemorrhagic Shock, Paper 185 |
| |
Marcos Balbino,
MD |
| |
University of São
Paulo Medical School, Brazil |
| 3:42
PM |
Paracrine Regulation
of Apoptosis by IL-1ß and IL-8-Stimulated PMN: |
| |
Differential Suppression
of FasL and TNF-a Induced Apoptosis |
| |
Paper 186 |
| |
Patricia S. Grutkoski,
PhD |
| |
Rhode Island Hospital,
Providence |
| 3:54
PM |
TNFR-I is Required
for Heat Stress Induction of Cytoprotective HSP70 in MØ, |
| |
Paper 187 |
| |
Julie K. Heimbach |
| |
University of Colorado
Health Sciences Center, Denver |
| |
Tuesday Continued |
| |
|
| 4:06
PM |
Cerebral Viability
After Grade IV Hemorrhage: Is Immediate Fluid |
| |
Resuscitation Necessary?,
Paper 188 |
| |
Reza Miraliakbari |
| |
East Carolina University
Brody School of Medicine, Greenville, North Carolina |
| 4:18
PM |
COX-1 Induction
and IL1ß Expression in Alveolar Macrophages After |
| |
Unilateral Chest
Trauma, Paper 189 |
| |
Wesley J. Desselle,
MD |
| |
University of Tennessee
Health Science Center, Memphis |
| 4:30
PM |
Alveolar Macrophage
TNF-a Release is Enhanced Following Trauma- |
| |
Hemorrhage and Sepsis,
Paper 190 |
| |
Doraid Jarrar, MD |
| |
Rhode Island Hospital,
Providence |
| 4:42
PM |
Lethal Septic Shock
Increases Myocardial UCP-2 Expression Coincident with |
| |
Myocardial Dysfunction,
Paper 191 |
| |
Michael J. Roshon |
| |
Carolinas Medical
Center, Charlotte, North Carolina |
| 4:54
PM |
Mechanisms of PMN
Persistence During Inflammation: Suppression of |
| |
Apoptosis by IL-8
and GRO-a Via Diverse Signaling Mechanisms |
| |
Paper 192 |
| |
Annmarie L. Dunican,
MD |
| |
Rhode Island Hospital,
Providence |
| 5:06
PM |
The Dissociation
Between Upregulated Endothelins and Hemodynamic |
| |
Responses During
Polymicrobial Sepsis, Paper 193 |
| |
David A. Ornan,
Sc.B |
| |
Rhode Island Hospital,
Providence |
| 5:18
PM |
Immediate Early
Genes (IEG) and Transcription Factors in Liver of Rats |
| |
Preconditioned with
Curcumin and Picroliv During Hemorrhagic Shock and |
| |
Resuscitation, Paper
194 |
| |
Gurmel S. Sidhu |
| |
Uniformed Services
University of Health Sciences, Bethesda, Maryland |
| 5:30
PM |
Genetic and Gender
Components in the Expression of Tumor Necrosis |
| |
Factor-a in Mice
During Endotoxemia, Paper 195 |
| |
F. Dylan Stewart,
MD |
| |
Johns Hopkins School
of Medicine, Baltimore, Maryland |
| 5:42
PM |
Two Stage Response
to Endotoxin Infusion into Normal Human Subjects, |
| |
Paper 196 |
| |
Fletcher B. Taylor,
Jr., MD |
| |
Oklahoma Medical
Research Foundation, Oklahoma City |
| 5:54
PM |
Closing Remarks |
| |
|
| |
|
| |
|
| 3:30 - 6:00 PM |
MINISYMPOSIUM IV,
Papers 197-208 |
| Ballroom 3 |
Moderators: Allan
M. Lefer, PhD, Thomas Jefferson University, Philadelphia, |
| |
Pennsylvania and
Lee-Wei Chen, MD, Veterans General Hospital, Kaohsiung, |
| |
Taiwan |
| |
|
| 3:30
PM |
Characterization
of Local and Systemic Cytokine Responses During Acute |
| |
Inflammation in
Humans, Paper 197 |
| |
Fernando A. Rivera-Chavez |
| |
University of Texas
Southwestern Medical Center, Dallas |
| 3:42
PM |
Safety and Efficacy
of Hypertonic Saline Dextran in Pediatric Patients |
| |
Submitted to Cardiac
Surgery with Cardiopulmonary Bypass, Paper 198 |
| |
Roberto Rocha e
Silva |
| |
University of São
Paulo, Brazil |
| 3:54
PM |
Prevention of Multiple
Organ Failure (MOF) Secondary to Severe Acute |
| |
Pancreatitis (SAP)
with Continuous Hemodiafiltration (CHDF) and Selective |
| |
Digestive Decontamination
(SDD), Paper 199 |
| |
Hiroyuki Hirasawa,
MD, PhD |
| |
Chiba University
School of Medicine, Japan |
| 4:06
PM |
Female Gender is
a Risk Factor for Early Postinjury Multiple Organ Failure, |
| |
Paper 200 |
| |
Patrick J. Offner,
MD |
| |
Denver Health Medical
Center, Colorado |
| 4:18
PM |
Hypoxia Inhibits
iNOS Expression in Endothelial Cells, Paper 201 |
| |
Haim Bitterman,
MD |
| |
Carmel Medical Center,
Haifa, Israel |
| 4:30
PM |
Nitric Oxide Pre-Treatment
Protects Against Peroxynitrite-Induced Enterocyte |
| |
Apoptosis, Paper
202 |
| |
Douglas A. Potoka,
MD |
| |
Children’s Hospital
of Pittsburgh, Pennsylvania |
| 4:42
PM |
The Absence of eNOS
Increases Mortality After Hemorrhagic Shock |
| |
Paper 203 |
| |
Vaishali D. Schuchert |
| |
University of Pittsburgh,
Pennsylvania |
| 4:54
PM |
Effects of n-Acetylcysteine
on Ischemic Brain Injury, Paper 204 |
| |
Salvatore Cuzzocrea,
PhD |
| |
University of Messina,
Italy |
| 5:06
PM |
Nitric Oxide Synthase
Inhibitor Ameliorates Oral Total Parenteral Nutrition- |
| |
Induced Barrier
Dysfunction, Paper 205 |
| |
Lee-Wei Chen, MD |
| |
Veterans General
Hospital, Kaohsiung, Taiwan |
| 5:18
PM |
Actin Cytoskeleton
and Endothelial Cell Response to Osmotic Stress, |
| |
Paper 206 |
| |
Saman Arbabi, MD |
| |
Harborview Medical
Center, Seattle, Washington |
| 5:30
PM |
Vascular Endothelial
Growth Factor (VEGF) Exerts Beneficial Effects in |
| |
Traumatic Shock
Via Preservation of Vascular Endothelial Function |
| |
Paper 207 |
| |
Allan M. Lefer,
PhD |
| |
Thomas Jefferson
University, Philadelphia, Pennsylvania |
| 5:42
PM |
Shock Induces Bone
Marrow Injury and a Migration of Hematopoietic |
| |
Precursors to Remote
Organs Which is Partially Mediated Through |
| |
Mesenteric Lymph,
Paper 208 |
| |
Devashish Anjaria,
MD |
| |
New Jersey Medical
School, Newark |
| 5:54
PM |
Closing Remarks |
| |
|
| |
|
| 6:30 - 7:30 PM |
RECEPTION |
| Ballroom Foyer |
|
| |
|
| 7:30 - 9:30 PM |
DINNER |
| Ballroom 1 &
2 |
|
