Twenty-Ninth Annual Conference on Shock
Attention all presenters! Be sure to read the presentation instructions.
Final Program Shock Society 2006
June 3 – 6, 2006
Meeting Registration Form (PDF)
Hotel Registration Form (PDF, 93k)
Saturday June 3, 2006
| 8:00 AM – 2:00PM |
Council Meeting
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| 12:00 – 6 PM |
Registration
|
| 12:00 – 1:30 PM |
Glue Grant Update
Ronald Tompkins
Massachusetts General Hospital, Boston, MA
Lunch will be provided by the Glue Grant. |
| 1:30 – 1:40 PM |
Welcome and Introductions
Daniel G. Remick, M.D.
University of Michigan, Ann Arbor, MI
|
| 1:45 – 3:45 PM |
Plenary Session (Oral Presentations)
| Chair: |
Patricia Molina, MD, PhD
Louisiana State University Health Sciences Center, New Orleans, LA
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| Co-Chair: |
Joseph Cuschieri, MD
University of Washington, Seattle, WA
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|
| 1:45 – 2:05 PM |
Ghrelin Inhibits Sympathetic Nervous Activity in Sepsis (Abstract 1)
Rongqian Wu, MD, PhD, Mian Zhou, MD, Padmalaya Das, PhD, Weifen Dong, MS, Youxin Ji, MD, Derek Yang, BS, Michael Miksa, MD, Thanjavur S. Ravikumar, MD, Ping Wang, MD
North Shore University Hospital-LIJ Medical Center, Manhasset, NY
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| 2:05 – 2:25 PM |
Differential Cell Death Gene Expression in Monocytes from LPS-Challenged Healthy Human Volunteers Pre-treated With Cortisol (Abstract 2)
Sonia M. Alvarez, MD, Michael T. Reddell, BS, Jacqueline E. Calvano, MS, Susette M. Coyle, MSN, RN, Marie Macor, RN, Ashwini Kumar, BS, Steven E. Calvano, PhD, Stephen F. Lowry, MD
UMDNJ-Robert Wood Johnson Medical School, New Brunswick, NJ
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| 2:25 – 2:45 PM |
Contribution of Nonapoptotic and Apoptotic FAS Signaling to the Pathology of Extrapulmonary Acute Lung Injury (Abstract 3)
Mario Perl, MD, Joanne Lomas-Neira, PhD, Ulrike Perl, RN, Chun-Shiang Chung, PhD, Alfred Ayala, PhD
Rhode Island Hospital, Providence, RI
|
| 2:45 – 3:05 PM |
Hypertonic Resuscitation of Hypovolemic Shock After Blunt Trauma: A Randomized Controlled Trial (Abstract 4)
Eileen Bulger, MD, Gregory Jurkovich, MD, Avery Nathens, MD, PhD, Michael Copass, MD, Sandra Hanson, RN, Claudette Cooper, RN, Ping-Yu Liu, PhD, Margaret Neff, MD, Keir Warner, BS, Ronald Maier, MD
University of Washington, Seattle, WA
|
| 3:05 – 3:25 PM |
Inhibition of Mitochondrial Respiratory Complex IV Abolishes ERβ-Mediated Cardio-Protection Following Trauma-Hemorrhage (Abstract 5)
Crystal Hsieh, PhD, Huang-Ping Yu, MD, Mashkoor A. Choudhry, PhD, Takao Suzuki, MD, Martin G. Schwacha, PhD, Kirby I. Bland, MD, Irshad H. Chaudry, PhD
University of Alabama at Birmingham, Birmingham, AL
|
| 3:25 – 3:45 PM |
Hepatic Injury and Systemic Inflammation After Trauma Requires TLR 4 and is Mediated by HMGB 1 (Abstract 6)
Ryan M. Levy, MD, Jose M. Prince, MD, Kevin P. Mollen, MD, Gregory Watson, MD, Kevin J. Tracey, MD, Mitchell P. Fink, MD, Yoram Vodovotz, PhD, Timothy R. Billiar, MD
University of Pittsburgh, Pittsburgh, PA
|
| 3:45 – 4:00 PM | Refreshment Break |
| 4:00 – 6:00 PM |
Joint Workshop with the Society for Leukocyte Biology (New this year) (Oral Presentations)
| Chair: |
Alfred Ayala, PhD
Rhode Island Hospital/Brown University, Providence, RI
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| Co-Chair: |
Sanna Goyert, PhD
North Shore-Long Island Jewish Medical Center, Manhasset, NY
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"The Role of Apoptotic Cells in Regulation of Inflammation"
Peter M. Henson, PhD, MD
Department of Pediatrics, National Jewish Medicine and Research Center, Louisville, KY
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"The Role of CD14 and Other Receptors in the Response to Bacterial Pathogens" (Abstract 7)
Sanna Goyert, PhD
Department of Medicine and Pathology, Institute for Medical Research, North Shore-LIJ, Manhasset, NY
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"Post-Transcriptional Regulation of Chemokine and Chemokine Receptor Expression During Inflammation" (Abstract 8)
Thomas A. Hamilton, PhD
Department of Immunology, The Cleveland Clinic Foundation, Cleveland, OH
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"CD40 Signaling and CD40/TLR Cross-Talk in Inflammation" (Abstract 9)
Jill Suttles, PhD
Department of Immunology and Microbiology, University of Louisville School of Medicine, Louisville, KY
|
| 6:15 – 7:15PM |
Presidential Address
"Standing on Shoulders: Mentors, Facilitators, Advocates, and Heroes"
Daniel J. Brackett, MD
University of Oklahoma Health Sciences Center, Oklahoma, OK
|
| 7:15 – 8:15 PM | Presidential Reception |
| 8:15 PM | DINNER - ON YOUR OWN |
Sunday June 4, 2006
| 7:00 – 8:00 AM | Continental Breakfast |
| 7:00 – 9:00 AM | Editorial Board Breakfast (Invitation only) |
| 7:00 – 10:00 AM |
Poster Session I (Abstracts P1 - P82)
- Renal, Abstracts P1-2
- Pulmonary, Abstracts P3-7
- Pharmacologic Agents, Abstracts P8-10
- Nitric Oxide, Abstracts P11-13
- Neutrophils, Abstracts P14-21
- Myocardial Function, Abstracts P22-25
- Multiple Organ Failure, Abstracts P26-27
- Monocytes/Macrophages, Abstracts P28-32
- Microcirculation, Abstracts P33-34
- Metabolism, Abstracts P35-36
- Liver, Abstracts P37-38
- Ischemia/Reperfusion, Abstracts P39-49
- Inflammation, Abstracts P67-73
- Cytokines, Abstracts P74-82
|
| 10:00 – 12:00 noon |
Symposium I: "Health Disparities" (Oral Presentations)
| Chair: |
Rosemary Kozar, MD, PhD
University of Texas Houston Medical Center, Houston, TX
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| Co-Chair: |
John Younger, MD, MS
University of Michigan Medical School, Ann Arbor, MI
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"Race and Medicine in the Genomic Era" (Abstract 10)
Jeff Long, PhD
Department of Human Genetics, University of Michigan Medical School, Ann Arbor, MI
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"Disparities in Sepsis" (Abstract 11)
Greg Martin, MD, MSc
Department of Pulmonary, Allergy and Critical Care, Emory University School of Medicine, Grady Memorial Hospital, Atlanta, GA
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"Impact of Race, Ethnicity and Socio-Economic Status on Health Disparities: Implications for the National Research Agenda" (Abstract 12)
Henri Ford, MD
Department of Surgery, Children's Hospital Los Angeles, Keck School of Medicine, University of Southern California
|
| 12:00 – 1:30 PM |
Lunch and Dinner with the Professor (New this year)
|
| Junior attendees at the conference may sign up when they pick up registration material to have lunch and/or dinner with a senior member of the Shock Society. This will allow networking between the young, vibrant attendees, and the more senior, experienced investigators. |
| 1:45 – 3:00 PM |
New Investigator Competition, with prize money (Oral Presentations)
| Chair: |
Basilia Zingarelli, MD, PhD
Cincinnati Children's Hospital Medical Center, Cincinnati, OH
|
|
| 1:45 – 2:00 PM |
CD8+ T Cells Promote Inflammation in the Liver After Sepsis (Abstract 13)
Doreen E. Wesche-Soldato, BS, Chun-Shiang Chung, PhD, and Alfred Ayala, PhD
Brown University/Rhode Island Hospital, Providence, RI
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| 2:00 – 2:15 PM |
The P13K/AKT Pathway Mediates the Non-Genomic Cardioprotective Effects of Estrogen Following Trauma-Hemorrhage (Abstract 14)
Huang-Ping Yu, MD, Y. Crystal Hsieh, PhD, Takao Suzuki, MD, Mashkoor A. Choudhry, PhD., Martin G. Schwacha, PhD, Kirby I. Bland, MD, Irshad H. Chaudry, PhD
University of Alabama at Birmingham, Birmingham, AL
|
| 2:15 – 2:30 PM |
Sepsis: Always in Mars (Abstract 15)
Marcin F. Osuchowski, DVM, PhD, Kathy Welch, MS, Huan Yang, MD, PhD, Javed Siddiqui, MS, Daniel G. Remick, MD
University of Michigan Medical School, Ann Arbor, MI
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| 2:30 – 2:45 PM |
Partial HIF-1? Deficiency Attenuates Ischemia Reperfusion-Mediated Gut and Lung Injury (Abstract 16)
Anthony C. Watkins, MD, Billy Abungu, BS, Maheswari Sentil, MD, Qi Lu, MD, Dimitrios Barlos, MD, Lauriston Prescott, BS, Francis J. Caputo, MD, Brendan K. McCracken, MD, Da-Zhong Xu, MD, Marta Bosch, PhD, George Semenza, MD, PhD, Edwin A. Deitch, MD, Rena Feinman, PhD
UMDNJ-New Jersey Medical School, Newark, NJ
|
| 2:45 – 3:00 PM |
TNFR1 Signaling Resistance in Female Myocardium is Mediated by Gender Differences in the STAT3/SOCS3 Pathway (Abstract 17)
Meijing Wang, MD, MS, Paul R. Crisostomo, MD, Eric D. Morrell, BS, Christine Herring, BS, Mathenge Wairiuko, MD, Daniel R. Meldrum, MD
Indiana University School of Medicine, Indianapolis, IN
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| 3:00 – 3:15 PM | Break |
| 3:15 – 5:15 PM |
Mini-Symposium I (Oral Presentations)
| Chair: |
Eileen Bulger, MD
University of Washington, Seattle, WA
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| Co-Chair: |
Jonathan McDunn, PhD
Washington University School of Medicine, St. Louis, MO
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|
| 3:15 – 3:30 PM |
PP2A Inhibition Attenuates Myocardial Dysfunction in Endotoxemia (Abstract 18)
Angela Lorts, MD, Timothy Burroughs, Thomas Shanley, MD
University of Michigan, Ann Arbor, MI
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| 3:30 – 3:45 PM |
The Interaction of Myocardial Depressant Factors in Endotoxemia: Role of TNF-α in TLR4-Mediated Expression of IL-1β and ICAM-1 (Abstract 19)
Xianzhong Meng, MD, PhD, Lihua Ao, BS, Yong Song, MD, Charles Dinarello, MD, Edward Abraham, MD
University of Colorado Health Sciences Center, Denver, CO
|
| 3:45 – 4:00 PM |
Role of HMGB1 in Apoptosis-Mediated Sepsis Lethality (Abstract 20)
Renqi Yuan, MD, Hui Li, MS, Haichao Wang, PhD, Mahendar Ochani, MD, Kanta Ochani, MD, Jared M. Huston, MD, Mauricio Rosas, MD, Chris J. Czura, MD, Kevin J. Tracey, MD, Huan Yang, PhD
The Feinstein Institute for Medical Research, Manhasset, NY
|
| 4:00 – 4:15 PM |
Adenosine A2A Receptor Inactivation Increases Survival in Polymicrobial Sepsis (Abstract 21)
Gyorgy Hasko, MD, PhD., Balazs Csoka, MS, Catherine Ledent, PhD, Zoltan Spolarics, MD, PhD, Qi Lu, PhD, Zoltan Nemeth, MD, PhD, Edwin Deitch, MD
UMDNJ-New Jersey Medical School, Newark, NJ
|
| 4:15 – 4:30 PM |
HSP70.1 and HSP70.3 Mediate Survival Following Cecal Ligation and Puncture in Aged Male Mice (Abstract 22)
Andrew T. Clark, MS, Kevin W. McConnell, MD, Clayton R. Hunt, PhD, Timothy G. Buchman, MD, PhD, Richard S. Hotchkiss, MD, Craig M. Coopersmith, MD
Washington University School of Medicine, St. Louis, MO
|
| 4:30 – 4:45 PM |
Glutamine's Attenuation of NF-?B and Mortality Following Sepsis are Dependent on HSP-70 Expression (Abstract 23)
Kristen Singleton, MS, Zung Vu Tran, PhD, Paul E. Wischmeyer, MD
University of Colorado Health Sciences Center, Denver, CO
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| 4:45 – 5:00 PM |
β-Arrestins Regulate Lipopolysaccharide (LPS)-Induced Signaling and Proinflammatory Gene Expression (Abstract 24)
Hongkuan Fan, PhD, Louis M. Luttrell, MD, PhD, Basilia Zingarelli, MD, PhD, Joseph J. Senn, PhD, George E. Tempel, PhD, Perry V. Halushka, MD, PhD, James A. Cook, PhD
Medical University of South Carolina, Charleston, SC
|
| 5:00 – 5:15 PM |
Regulatory T Cells are Increased but do not Participate in Mortality in Murine Polymicrobial Sepsis (Abstract 25)
Philip O. Scumpia, BS, Matthew J. Delano, MD, Lyle L. Moldawer, PhD
University of Florida, Gainesville, FL
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| 3:15 – 5:15 PM |
Mini-Symposium II (Oral Presentations)
| Chair: |
Saman Arbabi, MD
University of Michigan, Ann Arbor, MI
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| Co-Chair: |
Michelle Henry-Stanley, PhD
University of Minnesota, Minneapolis, MN
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|
| 3:15 – 3:30 PM |
Regulatory T-Cells Suppress the Development of the 2-Hit Response After Injury (Abstract 26)
Ann McKenna, MD, Malcolm MacConmara, MD, Satoshi Fujimi, MD, Adam Delisle, BS, John Mannick, MD, James Lederer, PhD
Brigham & Women's Hospital, Boston, MA
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| 3:30 – 3:45 PM |
The CD14 -159 C-Allele is Associated with Increased Risk of Mortality After Burns Injury (Abstract 27)
Robert Barber, PhD, Corinne Aragaki, PhD, Gary Purdue, MD, Brett Arnoldo, MD, John Hunt, MD, Ellen Chang, BS, Jureta Horton, PhD
UT Southwestern Medical Center, Dallas, TX
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| 3:45 – 4:00 PM |
Beneficial Effects of CpG DNA Treatment on Injury-Induced Changes in Host Immunity (Abstract 28)
Satoshi Fujimi, MD, Malcolm P. MacConmara, MD, Ann M. McKenna, MD, Adam Delisle, BS, Peter H, Lapchak, PhD, John A. Mannick, MD, James A. Lederer, PhD
Brigham and Women's Hospital/Harvard Medical School, Boston, MA
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| 4:00 – 4:15 PM |
Role of AIF in Trauma Hemorrhagic Shock Induced Endothelial Apoptosis (Abstract 29)
Dimitrios Barlos, MD, Anthony C. Watkins, MD, Billy Abungu, BS, Qi Lu, MD, Francis J. Caputo, MD, Da-Zhong Xu, MD, Rena Feinman, PhD, Edwin A. Deitch, MD
UMDNJ-New Jersey Medical School, Newark, NJ
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| 4:15 – 4:30 PM |
Are The Protective Effects of 17β-Estradiol on Splenic Macrophages and Splenocytes After Trauma-Hemorrhage Mediated Via Estrogen-Receptor (ER)-α or ER-β? (Abstract 30)
Frank Hildebrand, MD, William J. Hubbard, PhD, Mashkoor A. Choudhry, PhD, H-C. Pape, MD, Irshad H. Chaudry, PhD
Center for Surgical Research and the Department of Surgery, University of Alabama at Birmingham, Birmingham, AL
|
| 4:30 – 4:45 PM |
Gamma-Delta T Cells Use Heat Shock Protein 72 on the Cell Surface to Kill Activated PMN (Abstract 31)
Mark Hirsh, MD, PhD, Naoyuki Hashiguchi, MD, Yu Chen, MD, Wolfgang Georg Junger, PhD
UCSD, San Diego, CA
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| 4:45 – 5:00 PM |
Peroxisome Proliferator Activated Receptor 9 (PPAR9) and Liver X Receptor-α (LXRα) Cooperate in the Regulation of Macrophages (Abstract 32)
Giovanna Piraino, PhD, James A. Cook, PhD, Michael O'Connor, Paul W. Hake, Diana Teti, PhD, Basilia Zingarelli, MD, PhD
Cincinnati Children's Hospital Medical Center, Cincinnati, OH
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| 5:00 – 5:15 PM |
17β-Estradiol (E2) Administration After Major Blood Loss Improves Liver ATP, 3-Hour Survival and also Long-Term Survival Following Prolonged Hypotension (3 Hour) and Fluid Resuscitation (Abstract 33)
Jianguo Chen, MD, Laszlo Not, MD, Thian C. Ng, PhD, William J. Hubbard, PhD, John Chatham, PhD, Mashkoor A. Choudhry, PhD, Kirby I. Bland, MD, Irshad H. Chaudry, PhD
University of Alabama at Birmingham, Birmingham, AL
|
| 5:15 – 6:15 PM |
Start of Poster Session II (Abstracts P83-P168)
- Immunologic Dysfunction, Abstracts P83-P89
- Hemorrhagic Shock, Abstracts P90-P123
- Gene Regulation, Abstracts P124-P125
- Endotoxin/Sepsis, Abstracts P126-P168
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| 6:30 – 7:30 PM | Reception |
| 7:30 – 9:30 PM |
New Investigator Competition Ceremony
Travel Awards Ceremony
Dinner with the Professor
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Monday June 5, 2006
| 6:00 – 7:00 AM |
Twenty-Fourth Annual Presidential Fun Run
Organized by: Mark Clemens, MD
University of North Carolina at Charlotte
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| 7:00 – 9:00 AM | Continental Breakfast |
| 7:00 – 9:00 AM | Continuation of Poster Session II |
| 9:00 – 11:00 AM |
Symposium II: Presentations by authors from the most cited papers published in the journal, SHOCK (Oral Presentations)
| Chair: |
Irshad H. Chaudry, PhD, Shock Editor
University of Alabama at Birmingham, Birmingham, AL
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| Co-Chair: |
Christopher Thiemermann, PhD
William Harvey Research Institute, Centre for Experimental Medicine and Nephrology and Critical Care, University of London, London, England
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"Effect of Gender and Sex Hormones on the Immune Response Following Trauma - Potential Clinical Applications" (Abstract 34)
Martin Angele, MD, PhD
Department of Surgery, Klinikum Gro?hadern, Munich, Germany
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"Sepsis Syndromes: Understanding the Role of Innate and Acquired Immunity"
Lyle L. Moldawer, PhD
Department of Surgery, University of Florida, College of Medicine, Gainesville, FL
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"The Role of the Gut in Multiple Organ Failure (MOF)" (Abstract 35)
Frederick A. Moore, MD
Department of Surgery, University of Texas-Houston Medical Center, Houston, TX
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"Six at Six: The Inflammatory Response to Sepsis" (Abstract 36)
Daniel G. Remick, MD
Department of Pathology, University of Michigan Medical School, Ann Arbor, MI
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"Molecular Regulation of the Human Inducible Nitric Oxide Synthase (iNOS) Gene" (Abstract 37)
David A. Geller, MD
Starzl Transplantation Institute, University of Pittsburgh Medical Center, Pittsburgh, PA
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"The Role of NF-κB in Acute Lung Injury and Pulmonary Inflammation" (Abstract 38)
Edward Abraham, MD
Department of Medicine, University of Alabama at Birmingham, Birmingham, AL
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| 11:15 – 12:15 |
Shock Society Lecture
"Understanding Shock: The Contribution and Limitations of Morphology" (Abstract 39)
Sebastian Lucas, Head of Clinical Histopathology
Kings and St. Thomas School of Medicine, London, England
|
| 12:15 – 1:15 | Shock Business Meeting |
| 1:15 | Free Afternoon |
Whitewater rafting. During the free afternoon on Monday, June 5 two separate whitewater rafting trips have been arranged. Both these trips are offered by Highside Adventure Tours and are on Clear Creek. The first trip is the Clear Creek 1/3 Beginner trip at a cost of $33.17 per person and the second, more advanced trip is the 1/2 Intermediate trip for $39.95 per person. The trip will leave from the hotel and the transportation expense will be paid by the Shock Society. In the event that a trip does not fill the deposit will be refunded.
To reserve your spot for the trip send a check for the entire amount payable to Good Times Rafting. Send this check to Daniel Remick, M2210 Medical Science I Building, 1301 Catherine Road, Ann Arbor, MI 48109-0602 by May 10, 2006. Include your full name, phone number, and email address. Because of the discounted price refunds will not be available.
There may be additional space available on the trips at the time of the meeting, but it is best to reserve your spot in advance.
Tuesday June 6, 2006
| 7:00 – 9:00 AM | Continental Breakfast |
| 7:00 – 10:00 AM |
Poster Session III (Abstracts P169-P228)
- Clinical Applications, Abstracts P169-P170
- Cellular/Molecular, Abstracts P171-P174
- Cell Signaling, Abstracts P175-P189
- Burn/Trauma, Abstracts P189-P218
- Animal Models, Abstracts P219-P227
- Adhesion Molecules, Abstracts P228
|
| 10:00 – noon |
Workshop I: "Aging and Shock" (Oral Presentations)
| Chair: |
Elizabeth Kovacs, PhD
Loyola University Medical Center
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| Co-Chair: |
Antonio De Maio, PhD
University of California, San Diego
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"Aging and The Inflammatory Response After Traumatic Injury" (Abstract 40)
Elizabeth Kovacs, PhD
Department of Cell Biology, Neurobiology and Anatomy, Loyola University Medical Center, Maywood, IL
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"Modeling Aging and Sepsis" (Abstract 41)
Isaiah R. Turnbull, MD, PhD (Candidate)
Department of Surgery, Washington University School of Medicine, St. Louis, MO
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"Immune System Down the Drain: The Effects of Aging" (Abstract 42)
Antonio De Maio, MD
Department of Surgery, University of California, San Diego, LaJolla, CA
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"Increased IL-6 with Aging and Myocardial Dysfunction after Burn and Sepsis" (Abstract 43)
Weike Tao, MD
Department of Anesthesiology, The University of Texas-Southwestern, Dallas, TX
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| 12:00 – 1:30 PM |
Oral Presentations By and For New Investigators
| Chair: |
Cynthia Otto, DVM, PhD
University of Pennsylvania, Philadelphia, PA
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| In this session in which attendance and participation is limited to New Investigators, each brief (3-4 minute) oral presentation will be followed by a discussion period. This unique forum provides an opportunity for New Investigators to gain experience in presenting and discussing research with their peers. The only "Old Investigators" in attendance will be the moderators whose sole function will be to ensure that the talks start and stop on time. |
| 12:00 – 1:30 PM | Boxed Lunch |
| 1:30 – 3:15 PM |
Workshop II: "Advances in SIRS/Sepsis Heart Dysfunction" (Oral Presentations)
| Chair: |
Avadhesh Sharma, PhD
Department of Biomedical Sciences, The Texas A&M University System Health Science Center Baylor College of Dentistry, Dallas, TX
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| Co-Chair: |
Jureta Horton, PhD
Department of Surgery, University of Texas Southwestern Medical Center at Dallas, Dallas, TX
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"Sepsis-Induced Myocardial Dysfunction" (Abstract 44)
Avadhesh C. Sharma, PhD
The Texas A&M University System Health Science Center Baylor College of Dentistry, Dallas, TX
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"Left Ventricular Function in Burn and Burn Complicated by Sepsis" (Abstract 45)
Jureta Horton, PhD
Department of Surgery, UT Southwestern Medical Center at Dallas, Dallas, TX
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"Myocardial Depression in Pediatric Sepsis; Clinical and Molecular Advances" (Abstract 46)
Angela Lorts, MD
Department of Pediatrics and Communicable Disease, Michigan Medical School, Ann Arbor, MI
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"Sepsis Induced Myocardial Dysfunction is Accompanied by Sepsis Induced Myocardial Protection" (Abstract 47)
Kathleen McDonough, PhD
Department of Physiology, Louisiana State University Health Science Center, New Orleans, LA
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"The Cardiac Purine Metabolome During Sepsis" (Abstract 48)
William R. Law, PhD
Department of Physiology & Biophysics, University of Illinois at Chicago, Chicago, IL
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"Mitochondrial Resuscitation With Exogenous Cytochrome C in the Septic Heart" (Abstract 49)
Richard J. Levy, MD
Department of Anesthesiology, Children's Hospital of Philadelphia, Philadelphia, PA
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| 3:30 – 4:30 PM |
New Technologies and Models (Oral Presentations)
| Chair: |
Ernest Moore, MD
University Colorado Health Sciences Center, Denver, CO
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| Co-Chair: |
Philip Scumpia, MD
University of Florida, Gainesville, FL
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"Technologies and Approaches to Determining the Effects of Genetic Variation"
Grant O'Keefe, MD
Department of Surgery, University of Washington, Harborview Medical Center, Seattle, WA
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"A Non-Human Primate Model of Anthrax Sepsis" (Abstract 50)
Shinichiro Kurosowa, MD, PhD
Department of Free Radical Biology & Aging Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK
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| 4:30 – 6:00 PM |
Mini-Symposium III (Oral Presentations)
| Chair: |
Nilofer Qureshi, PhD
University of Missouri, Kansas City, MO
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| Co-Chair: |
Jean Nemzek, D.V.M.
University of Michigan, Ann Arbor, MI
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| 4:30 – 4:40 PM |
Insights into the Mechanisms of Human Stem Cell Activation (Abstract 51)
Paul R. Crisostomo, MD, Meijing Wang, MD, MS, Christine M. Herring, BS, George M. Wairiuko, MD, Daniel R. Meldrum, MD
Indiana University School of Medicine, Indianapolis, IN
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| 4:40 – 4:50 PM |
The Role of Caspase-Mediated Cardiac Dysfunction Associated With Burn Trauma (Abstract 52)
Deborah L. Carlson, PhD, Jureta W. Horton, PhD
Southwestern Medical Center, Dallas, TX
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| 4:50 – 5:00 PM |
The Renin-Angiotensin System is Associated with Impaired Insulin Receptor Signaling in Burn Injury (Abstract 53)
Sherry O. Kasper, PhD, Scott M. Castle, BS, Brynn Voy, PhD, Blaine L. Enderson, MD, Brian J. Daley, MD, Michael D. Karlstad, PhD
University of Tennessee Graduate School of Medicine, Knoxville, TN
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| 5:00 – 5:10 PM |
Mechanism of p38 MAPK Signaling in Kupffer Cells (KC) Following Hypoxia: Regulation by Src Family Kinases (Abstract 54)
Bjoern Thobe, MD, Mashkoor A. Choudhry, PhD, Martin G. Schwacha, PhD, Kirby I. Bland, MD, Irshad H. Chaudry, PhD
University of Alabama at Birmingham Birmingham, AL
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| 5:10 – 5:20 PM |
Microtubule Disruption Inhibits TNF α-Induced NF-κB Nuclear Translocation Independent of IκB Degradation (Abstract 55)
Trevor L. Nydam, MD, Robert C. McIntyre, MD, Ernest E. Moore, MD, Guillermo A. Escobar, MD, Christine Hamiel, BS, Fabia Gamboni-Robertson, PhD, Nathan McLaughlin, BS, Anirban Banerjee, PhD
University of Colorado Health Sciences Center, Denver, CO
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| 5:20 – 5:30 PM |
The C5A Priming Effect Enhances TNFα Translation Through the P13K/AKT/MTOR Pathway (Abstract 56)
Valerie Schaeffer, PhD, Joseph Cuschieri, MD, Iris Garcia, BS, Megan Knoll, BS, Eileen Bulger, MD, Ronald Maier, MD
Harborview Medical Center, Seattle, WA
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| 5:30 – 5:40 PM |
A Peptide Agonist of AKT-Signaling Abrogates Sepsis-Induced Lymphocyte Apoptosis (Abstract 57)
Jonathan E. McDunn, PhD, Chris Davis, BS, Jared Muenzer, MD, Anne Drewry, BS, Richard S. Hotchkiss, MD
Washington University School of Medicine, St. Louis, MO
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| 5:40 – 5:50 PM |
Hypertonic Saline Inhibits C5A Priming of the PMN Via Arrest of C5A Receptor Endocytosis (Abstract 58)
Lynn Gries, MD, Ernest E, Moore, MD, Nathan McLaughlin, BS, Philip Eckels, BS, Jeffrey L. Johnson, MD, Christopher C. Silliman, MD, PhD
Department of Surgery, Denver Health Medical Center and UCHSC, Denver, CO
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| 5:50 – 6:00 PM |
Blunt Chest Trauma Induces Apoptosis in Alveolar Type 2 Epithelial Cells Via FAS-L Binding (Abstract 59)
Daniel H. Seitz*, MD, Mario Perl, MD, Stefanie Mangold*, Max G. Bachem*, MD, Shaoxia Zhou*, MD, Sonja T. Braumuller*, Markus S., Huber Lang, MD, Markus W. Knoferl, MD
University of Ulm, Germany
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| 4:30 – 6:00 PM |
Mini-Symposium IV (Oral Presentations)
| Chair: |
Laurie Kilpatrick, PhD
The Children's Hospital of Philadelphia, Philadelphia, PA
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| Co-Chair: |
Evan Nadler, MD
New York University School of Medicine, New York, NY
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| 4:30 – 4:40 PM |
Epidermal Growth Factor (EGF) Attenuates LPS-Mediated Signaling in Enterocytes Through Reduced Expression of Toll Like Receptor 4 During Endotoxemic Stress (Abstract 60)
Janet J. Fan, Cynthia L. Leaphart, MD, Jamie Cavallo, BS, Rahul J. Anand, MD, Jun Li, BS, David J. Hackam, MD, PhD
Children's Hospital of Pittsburgh, Pittsburgh, PA
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| 4:40 – 4:50 PM |
Advanced Age Exacerbates the Pulmonary Inflammatory Response After Lipopolysaccharide Exposure (Abstract 61)
Christian R. Gomez, PhD, Shirin Birjandi, MS, Stefanie Hirano, BS, Brent T. Cutro, BS, Horea Baila, MD, Vanessa Nomellini, BS, Elizabeth J. Kovacs, PhD
Loyola University Medical Center, Maywood, IL
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| 4:50 – 5:00 PM |
Depressed T-Cell Function is Responsible for Diminished Cell-Mediated Immunresponses Following Trauma-Hemorrhage (Abstract 62)
Christian R. Walz, Predoctoral Student, Siegfried Zedler, PhD, Christian Schneider, MD, Stefan Mayr, MD, Eugen Faist, MD, Irshad H. Chaudry, PhD, Karl-Walter Jauch, MD, Martin K. Angele, MD
Department of Surgery, University of Alabama at Birmingham, Birmingham, AL
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| 5:00 – 5:10 PM |
Pancreatic Proteases are Necessary for Increased Gut Epithelial Permeability During Trauma/Hemorrhagic Shock (Abstract 63)
Francis J. Caputo, MD, Anthony C. Watkins, MD, Dennis Vega, MD, Dimitrios Barlos, MD, Qi Lu, MD, Da-Zhong Xu, MD, Edwin A. Deitch, MD
New Jersey Medical School, University of Medicine and Dentistry of New Jersey, Newark, NJ
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| 5:10 – 5:20 PM |
Fresh Whole Blood is the Best 24-h Hypotensive Resuscitative Fluid in Severe Hemorrhage in Swine (Abstract 64)
Jill L. Sondeen, PhD, Charles E. Wade, PhD, Michael A. Dubick, PhD, M. Dale Prince, BS, John B. Holcomb, MD
U.S. Army Institute of Surgical Research, Ft. Sam Houston, TX
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| 5:20 – 5:30 PM |
Oxidative Metabolism and Expression of Cell Surface Receptors on Monocytes and Neutrophils in Patients with Sepsis, Severe Sepsis, and Septic Shock (Abstract 65)
Paulo Sergio Martins, MD, Milena KC Brunialti, PhD, Leandro Martos, Fellow, Flavia Machado, MD, Murillo Assuncao, MD, Sergio Blecher, MD, Reinaldo Salomao, MD
Federal University of Sao Paulo, Sao Paulo, Brazil
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| 5:30 – 5:40 PM |
Plasma Fraction From Stored Packed Red Blood Cells Induces Acute Lung Injury in an In Vivo Rodent Two Event Model (Abstract 66)
Tomohiko Masuno, MD, Ernest E. Moore, MD, Sagar Damle, MD, Aaron M. Cheng, MD, Marguerite Kelher, BS, Christopher C. Silliman, MD,PhD
Department of Surgery, Denver Health Medical Center and UCHSC, Denver, CO
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| 5:40 – 5:50 PM |
Loss of the Circadian Pattern of Adreno-Cortical Secretion in Sepsis is Associated with Increased Neuronal Activity and Content of CRH (Abstract 67)
Drew E. Carlson, PhD, Gloria E. Hoffman, PhD, William C. Chiu, MD
University of Maryland School of Medicine, Baltimore, MD
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| 6:30 – 7:30 PM | Reception |
| 7:30 – 9:30 PM | Dinner, Scientific Achievements, and Service Awards Ceremony |
Notes on poster sessions: Each poster session lasts 3 hours. Presenters are expected to be available beside their poster for 1 hour so that questions may be asked and answered. Each presenter will be arbitrarily assigned to a specific time.
- Poster Session I
- Sunday June 4th, 7:00 – 10:00 AM
- Section A: 7:00 – 8:00 AM
- Section B: 8:00 – 9:00 AM
- Section C: 9:00 – 10:00 AM
- Poster Session II
- Sunday June 4th, 5:15 – 6:15 PM continuing Monday June 5th, 7:00 – 9:00 AM
- Section A: 5:15 – 6:15 PM
- Section B: 7:00 – 8:00 AM
- Section C: 8:00 – 9:00 AM
- Poster Session III
- Tuesday June 6th, 7:00 – 10:00 AM
- Section A: 7:00 – 8:00 AM
- Section B: 8:00 – 9:00 AM
- Section C: 9:00 – 10:00 AM
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